99586-66-0

99586-66-0 - Names and Identifiers

Name	2-AMino-4-chloro-6-MethylpyriMidine-5-carbonitrile
Synonyms	2-Amino-4-chloro-6-methyl-5-pyrimidinecarbonitrile 2-AMino-4-chloro-6-MethylpyriMidine-5-carbonitrile 5-Pyrimidinecarbonitrile, 2-amino-4-chloro-6-methyl-
CAS	99586-66-0

99586-66-0 - Physico-chemical Properties

Molecular Formula	C6H5ClN4
Molar Mass	168.58
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C

99586-66-0 - Risk and Safety

HS Code

29335990

99586-66-0 - Reference Information

Application

2-amino-4-chloro-6-methylpyrimidine-5-carbonitrile (4-chloro-5-iodo-6-methyl) pyrimidine -2-Amine, it can be prepared from 4-chloro-6-methylpyrimidin-2-amine by a two-step reaction. 2-amino-4-chloro-6-methylpyrimidine-5-carbonitrile can be used for the preparation of (S)-2-amino -4-((1-(3-chloro-5-phenylpyrazole [1,5-a] pyrimidin-6-yl) ethyl) amino)-6-methylpyrimidine-5-carbonitrile, which is a PI3K inhibitor.

preparation

in a ML round-bottom flask, 4-chloro-6-methylpyrimidin-2-amine (3G, 21.0mmol) was dissolved in 40ml glacial acetic acid and cooled to below 10 °c in an ice bath. NIS(2.4g,10.6mmol) was added to the upper solution, and after reacting for 1 hour, NIS(2.4g,10.6mmol) was added again, and after reacting for 1 hour, it was naturally raised to room temperature and reacted for 8 hours. After completion of the reaction, the reaction solution was poured into ice water and extracted with EtOAc. The organic phase was washed with 5%Na2SO3 solution, 10% NaHCO3 solution and saturated NaCl solution, and dried over anhydrous Na2SO4, after filtration, the solvent was removed by concentration under reduced pressure to obtain 87% G of a solid, that is, 2-amino-4-chloro-6-methylpyrimidin-5-carbonitrile.

Last Update：2024-04-10 22:29:15