999-97-3
1,1,1,3,3,3-Hexamethyldisilazane
CAS: 999-97-3
Molecular Formula: C6H19NSi2
999-97-3 - Names and Identifiers
| Name | 1,1,1,3,3,3-Hexamethyldisilazane |
| Synonyms | HMDS ((CH3)3Si)2NH DYNASYLAN HMDS HEXAMETHYLDISILAZANE Hexamethyldisilazane hexamethyl disilizane HEXAMETHYLDISILYLAMINE Bis(trimethylsilyl)amine BIS(TRIMETHYLSILYL)AMINE 1,1,1,3,3,3,-HEXAMETHYLDISILA- 1,1,1,3,3,3-Hexamethyldisilazane 1,1,1,3,3,3-hexamethyl-disilazan 1,1,1-trimethyl-n-(trimethylsilyl)-silanamin |
| CAS | 999-97-3 |
| EINECS | 213-668-5 |
| InChI | InChI=1/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3 |
999-97-3 - Physico-chemical Properties
| Molecular Formula | C6H19NSi2 |
| Molar Mass | 161.39 |
| Density | 0.765 |
| Melting Point | -78℃ |
| Boling Point | 125℃ |
| Flash Point | 20℃ |
| Water Solubility | REACTS |
| Vapor Presure | 20 hPa (20 °C) |
| Refractive Index | 1.4069 |
| Physical and Chemical Properties | Colorless transparent liquid, non-toxic, slightly amine flavor |
| Use | Amikacin pharmaceutical intermediates, hydroxyl and amino protective agent; Special organic synthesis. Amikacin, penicillin, cephalosporin, fluorouracil and various penicillin derivatives in the synthesis process of Silylation. Surface treatment of diatomite, silica, titanium and other powders. Adhesion aids for Photoresists in the semiconductor industry. |
999-97-3 - Risk and Safety
| Hazard Symbols | F - Flammable C - Corrosive  |
| Risk Codes | R11 - Highly Flammable R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R34 - Causes burns |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3286 3/PG 2 |
999-97-3 - Upstream Downstream Industry
999-97-3 - Nature
| chemical properties |
Hexamethyldisilazane, the English abbreviation HMDS, is an important organosilicon compound, colorless and transparent liquid. Easy to hydrolyze, release NH3, generate hexamethyldisilyl ether. In the presence of a catalyst, it reacts with alcohol or phenol to produce trimethylalkoxysilane or trimethylaryloxy silane. Reacts with anhydrous hydrogen chloride to release NH3 or NH4Cl to produce trimethylchlorosilane. |
| chemical properties | colorless, transparent and easy-to-flow liquid. Boiling point 125 ℃, relative density 0.76(20/4 ℃). Dissolved in an organic solvent, it will be quickly hydrolyzed to form trimethylsilanol and hexamethyldisilyl ether in contact with air. Flash point -1 ℃. |
Last Update：2024-04-10 22:29:15
999-97-3 - Security information
| category | flammable liquid |
| toxicity classification | Poisoning |
| acute toxicity | oral-rat LD50: 850 mg/kg; Oral-mouse LDL0: 850 mg/kg |
| flammability hazard characteristics | It is flammable in case of open flame, high temperature, and oxidant; it decomposes toxic silicide gas in case of water; combustion produces toxic nitrogen oxide smoke |
| storage and transportation characteristics | The warehouse is ventilated and dry at low temperature; it is stored separately from oxidants and acids |
| fire extinguishing agent | dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent |
Last Update：2024-04-10 22:29:15
999-97-3 - Nature
| melting point | -78 °C |
| boiling point | 125°C (lit.) |
| density | 0.774 g/mL at 25 °C(lit.) |
| vapor density | 4.6 (vs air) |
| Vapor pressure | 20 hPa (20 °C) |
| refractive index | n20/D 1.407(lit.) |
| flash point | 57.2 °F |
| storage conditions | Store below +30°C. |
| solubility | Miscible with acetone, benzene, ethyl ether, heptane and perchloroethylene. |
| morphology | Liquid |
| acidity coefficient (pKa) | 30(at 25℃) |
| color | Colorless |
| Specific gravity | 0.774 |
| Odor | Ammonia odour |
| pH range of acid-base indicator discoloration | 8.5 |
| explosion limit value (explosive limit) | 0.8-25.9%(V) |
| water solubility | REACTS |
| hydrolysis sensitivity | 7: reacts slowly with moisture/water |
| sensitivity | Moisture Sensitive |
| Merck | 14,4689 |
| BRN | 635752 |
| InChIKey | FFUAGWLWBBFQJT-UHFFFAOYSA-N |
| NIST chemical information | Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-(999-97-3) |
| EPA chemical information | Hexamethyldisilazane (999-97-3) |
Last Update：2024-04-10 22:29:15
999-97-3 - Use
In organosilazane chemistry, hexamethyldisilazane can be used for chlorine exchange with chlorosilane monomers to obtain polysilazane. This method has great advantages over direct ammonia method in synthesis.
It is a medicinal intermediate of amikacin, a hydroxyl and amino protective agent
Silanizing reagent, which can be used in the production of cesidocanamycin.
Used in the production of rubber and drugs. This product is a tail-reducing agent that reduces the adsorption activity on the surface of the gas chromatography carrier. Silanizing reagent, which can be used in the production of cesidokanamycin. Hexamethyldisilazane is a medicinal intermediate of amikacin, which is a hydroxyl and amino protective agent; special organic synthesis. Silylation in the synthesis of amikacin, penicillin, cephalosporin, fluorouracil and various penicillin derivatives. Surface treatment of diatomite, white carbon black, titanium and other powders. Bonding aid for photoresist in semiconductor industry. It is a medicinal intermediate of amikacin, which is a hydroxyl and amino protective agent
Basic silanized protective agent, inorganic filler treatment agent
production method
dissolve 109g(1.0mol) trimethylchlorosilane in 500ml of anhydrous ether, introduce ammonia gas, and immediately appear white precipitate. Heat to reflux, slowly pass ammonia for 6 hours, settle and filter ammonium chloride, take ether solution to evaporate ether first, then evaporate hexamethyldisilane to obtain 52.5g with 65% yield.
Last Update：2024-04-10 22:29:15
999-97-3 - Security information
| dangerous goods mark | F,C,Xn |
| hazard category code | 11-20/21/22-34-52/53 |
| safety instructions | 16-26-36/37/39-45-61 |
| dangerous goods transport number | UN 3286 3/PG 2 |
| WGK Germany | 2 |
| RTECS number | JM9230000 |
| F | 21 |
| auto-ignition temperature | 325 °C |
| Hazard Note | Flammable |
| TSCA | Yes |
| customs code | 2931 90 00 |
| HazardClass | 3 |
| PackingGroup | II |
| toxic substance data | 999-97-3(Hazardous Substances Data) |
| Toxicity | LDLO I .p. in mice: 650 mg/kg (Petrarch Systems Inc. Product Information Sheets) |
Last Update：2024-04-10 22:29:15
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View History
Raw Materials for 999-97-3
Downstream Products for 999-97-3
beta-Methyl vinyl phosphate (MAP)
(2R)-2-[(4-Ethyl-2,3-dioxopiperazinyl)carbonylamino]-2-phenylacetic acid
Sodium bis(trimethylsilyl)amide
6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE
6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE
Tegafur
Imidodisulfurylfluoride
N-(Trimethylsilyl)-2-[(trimethylsilyl)oxy]pyrimidin-4-amine
(2R)-2-[(4-Ethyl-2,3-dioxopiperazinyl)carbonylamino]-2-phenylacetic acid
Sodium bis(trimethylsilyl)amide
6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE
6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE
Tegafur
Imidodisulfurylfluoride
N-(Trimethylsilyl)-2-[(trimethylsilyl)oxy]pyrimidin-4-amine