A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMAMIDE

Name	N-Phenyl-3,4-Dihydroxybenzylidenecyanoacetamide
Synonyms	AG 494 TYRPHOSTIN B48 TYRPHOSTIN AG 494 A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMAMIDE ALPHA-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE N-PHENYL-3,4-DIHYDROXYBENZYLIDENECYANOACETAMIDE N-Phenyl-3,4-Dihydroxybenzylidenecyanoacetamide (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-PHENYL-2-PROPENAMIDE
CAS	133550-35-3

Molecular Formula	C16H12N2O3
Molar Mass	280.28
Melting Point	249 °C(dec.)
Solubility	DMSO: soluble
Appearance	Yellow solid.
Color	Light yellow to Amber to Dark green
Storage Condition	Keep in dark place,Sealed in dry,2-8°C
In vitro study	In DHER-14 cells, AG 494 inhibits Cdk2 activation and EGF-dependent DNA synthesis. AG-494 significantly prevents NF-kB activation in silica-stimulated cells, and also reduces NF-kB activation in H 2 O 2 -treated cells. AG-494 (3-9 μM; 5-7 days) inhibits BMP9-induced ALP activity in a dose-dependent manner.

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
UN IDs	3439
WGK Germany	3
Hazard Class	6.1
Packing Group	III

Last Update：2024-01-02 23:10:35

biological activity	AG-494 is an inhibitor of EGFR receptor autophosphorylation with an IC50 of 1.2 μm. It inhibits EGF-dependent cell growth with an IC50 of 6 μm.
Target	Value
EGFR (Cell-free assay)	1.2 μM

Last Update：2024-04-10 22:29:15

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A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMAMIDE

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