ABBV-974
GLPG1837
CAS: 1654725-02-6
Molecular Formula: C16H20N4O3S
ABBV-974 - Names and Identifiers
| Name | GLPG1837 |
| Synonyms | ABBV974 ABBV974 ABBV 974 GLPG1837 ABBV-974 GLPG 1837 ABBV 974 GLPG1837 ABBV-974 GLPG-1837 BMS-935177 GLPG 1837 1654725-02-6 GLPG-1837(ABBV-974) |
| CAS | 1654725-02-6 |
ABBV-974 - Physico-chemical Properties
| Molecular Formula | C16H20N4O3S |
| Molar Mass | 348.42 |
| Density | 1.326±0.06 g/cm3(Predicted) |
| Boling Point | 443.2±45.0 °C(Predicted) |
| pKa | 11.21±0.10(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | GLPG1837 has good in vitro ADME properties (ADME: aborption, distribution, metabolism, excretion), in the stability analysis of microsomes and hepatocytes, GLPG1837 has a lower Clint,unb, good cell permeability, no off-target inhibition of CYPs and hERG channels. |
| In vivo study | The pharmacokinetic properties of GLPG1837 are good, with low Cl,unb and good oral bioavailability in rats and dogs. In rats and dogs, 1 mg/kg of GLPG1837 was injected intravenously with clearance rates (CL) of 1.92 and 0.32 L/h/kg, respectively. In rats T 1/2 is 1.84 hours, while in dogs T 1/2 is 3 hours. The oral bioavailability of GLPG1837 was 67% in rats and greater than 100 in dogs when administered by the oral route at 5 mg/kg. |
ABBV-974 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.87 ml | 14.35 ml | 28.701 ml |
| 5 mM | 0.574 ml | 2.87 ml | 5.74 ml |
| 10 mM | 0.287 ml | 1.435 ml | 2.87 ml |
| 5 mM | 0.057 ml | 0.287 ml | 0.574 ml |
Last Update：2024-01-02 23:10:35
ABBV-974 - Reference Information
| biological activity | GLPG1837 (ABBV-974) is a novel CFTR Potentiator with an EC50 of 3 nM for F508del. Compared to Ivacaftor, it has an enhancing effect on CFTR mutants with class III mutations. |
| Target | Value |
| CFTR(F508del) () | 3 nM(EC50) |
| CFTR(G551D) () | 339 nM(EC50) |
Last Update：2024-04-10 22:29:15
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Product Name: GLPG1837 Visit Supplier Webpage Request for quotationCAS: 1654725-02-6
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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