ABDP
Alendronic Acid
CAS: 66376-36-1
Molecular Formula: C4H13NO7P2
ABDP - Names and Identifiers
| Name | Alendronic Acid |
| Synonyms | ABDP ALENDRONATE Alendronic Acid ALENDRONIC ACID a-hydroxy-d-aminobutylidenediphosphonic acid (4-AMINO-1-HYDROXYBUTYLIDENE)DIPHOSPHONIC ACID (4-amino-1-hydroxybutylidene)bis-phosphonicaci (4-Amino-1-hydroxybutylidene)bisphosphonic acid 4-AMINO-1-HYDROXY-1,1-BUTYLIDINEDIPHOSPHONIC ACID (4-AMINO-1-HYDROXYBUTYLIDENE)-BIS-(PHOSPHONIC ACID) 4-amino-1-hydroxybutylidene-1,1-bis(phosphonicacid) (4-AMINO-1-HYDROXY-1-PHOSPHONOBUTYL)PHOSPHONIC ACID |
| CAS | 66376-36-1 |
| EINECS | 204-352-8 |
| InChI | InChI=1/C4H13NO7P2/c5-3-1-2-4(6,13(7,8)9)14(10,11)12/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12) |
ABDP - Physico-chemical Properties
| Molecular Formula | C4H13NO7P2 |
| Molar Mass | 249.1 |
| Density | 1.857±0.06 g/cm3(Predicted) |
| Melting Point | 230-235°C |
| Boling Point | 616.7±65.0 °C(Predicted) |
| Water Solubility | Insoluble in water |
| Appearance | powder to crystal |
| Color | White to Light yellow |
| Merck | 14,229 |
| pKa | pK1 2.72 ±0.05; pK2 8.73 ±0.05; pK3 10.5 ±0.1; pK4 11.6 ±0.1 at 25°, (0.1M KCl) |
| Storage Condition | Room Temprature |
| MDL | MFCD00868112 |
| Physical and Chemical Properties | Fine white powder, melting point 233~235 C (decomposition). pKl 2.72±0.05;pK2 8.73±0.05;pK3 10.5±0.1;pK4 11.6±0.1(2512,0.1mol/L potassium chloride). |
| In vitro study | Bisphosphonates are widely used in the treatment of osteoporosis, and among the bisphosphonates, alendronic acid is the most frequently prescribed drug. Bisphosphonates have powerful inhibitory effects on bone remodeling, a process that is critically important for fracture healing. |
ABDP - Risk and Safety
| UN IDs | 1759 |
| RTECS | SZ6521833 |
| Hazard Class | 8 |
| Packing Group | III |
ABDP - Nature
Open Data Verified Data
fine white powder, melting point 233-235 ° C. (decomposition).
Last Update：2024-01-02 23:10:35
ABDP - Preparation Method
Open Data Verified Data
In 4-aminobutyric acid and phosphoric acid, phosphorus trihalide was added dropwise for reaction. When the reactants had hardened, they were heated again, water was added for hydrolysis, and after cooling, methanol was added and alendronic acid was collected.
Last Update：2022-01-01 09:24:24
ABDP - Use
Open Data Verified Data
alendronate sodium was previously developed by isitutogentili, Italy, and later transferred to Merck, USA, for continued development and Merck, Inc. for development. It was first launched in Italy in 1993. Bisphosphonate inhibitors of bone resorption. For the treatment of osteoporosis.
Last Update：2022-01-01 09:24:25
ABDP - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | alendonic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid has a therapeutic effect on postmenopausal osteoporosis, malignant hypercalcemia and Paget's disease. |
| Use | bisphosphonate bone resorption inhibitors. For the treatment of osteoporosis. |
| production method | 1mol of 4-aminobutyric acid is added to 1mol of molten 1.5mol of phosphoric acid at 95 °c, then 2mol of phosphorus trihalide was added dropwise over 60min. After the reaction had hardened, the reaction was heated for an additional 3H. Hydrolysis was carried out by addition of 64.6% ml of water, after cooling it was poured into ml of methanol, and the precipitate was collected to give of alendronic acid. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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