AC1LYELL
CCF642
CAS: 346640-08-2
Molecular Formula: C15H10N2O4S3
AC1LYELL - Names and Identifiers
AC1LYELL - Physico-chemical Properties
| Molecular Formula | C15H10N2O4S3 |
| Molar Mass | 378.45 |
| Density | 1.60±0.1 g/cm3(Predicted) |
| Boling Point | 567.3±60.0 °C(Predicted) |
| Solubility | DMSO: ≥ 30 mg/mL |
| Appearance | powder |
| Color | yellow to orange |
| pKa | -0.70±0.20(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | In vitro experiments, CCF642 inhibits PDI reductase activity, which is more potent than the inhibitory activity of the different structural, proven inhibitors PACMA 31 and loc14. A new covalent binding pattern of its active site CGHCK motif was found by computer modeling. CCF642 causes acute endoplasmic reticulum stress in multiple myeloma cells with apoptosis-induced calcium release. |
| In vivo study | CCF642 has powerful efficacy in a syngeneic mouse model of aggressive multiple myeloma, extending the lifespan of C57BL/Kalwij mice transplanted with 5TGM1-luc myeloma. |
AC1LYELL - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.642 ml | 13.212 ml | 26.424 ml |
| 5 mM | 0.528 ml | 2.642 ml | 5.285 ml |
| 10 mM | 0.264 ml | 1.321 ml | 2.642 ml |
| 5 mM | 0.053 ml | 0.264 ml | 0.528 ml |
Last Update：2024-01-02 23:10:35
AC1LYELL - Reference Information
| biological activity | CCF642 (AC1LYELL) is a new type of protein disulfide isomerase (PDI) inhibitor with anti-myeloma activity. |
| target | TargetValue protein disulfide isomerases |
| Target | Value |
| in vitro study | in vitro experiments, CCF642 inhibited PDI reductase activity, which is more effective than the inhibitory activity of PACMA 31 and LOC14, which have been proved to be different structures. A new covalent binding pattern of its active site CGHCK motif was found by computer modeling. CCF642 causes acute endoplasmic reticulum stress in multiple myeloma cells, accompanied by apoptosis-induced calcium release. |
| in vivo study | CCF642 has a powerful effect in the synaptic mouse model of aggressive multiple myeloma, which can extend the transplantation of 5TGM1-luc C57BL/KaLwRij mice life span. |
Last Update：2024-04-10 22:41:03
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Spot supply
Product Name: CCF642 Visit Supplier Webpage Request for quotationCAS: 346640-08-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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