ADAP-IMH

Name	CD437
Synonyms	CD437 ADAP-IMH ADAP-IME Adapalene IMpurity F O-DesMethyl Adapalene AHPN, 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid 6-(4-hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphenyl)-2-naphthalenecarboxylic 2-naphthalenecarboxylicacid,6-(4-hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphen
CAS	125316-60-1
EINECS	200-258-5

Molecular Formula	C27H26O3
Molar Mass	398.49
Density	1.290
Melting Point	271.6-276°C
Boling Point	595.0±50.0 °C(Predicted)
Solubility	DMSO: 26mg/mL
Appearance	solid
Color	yellow
pKa	4.17±0.30(Predicted)
Storage Condition	-20°C
In vitro study	CD437 is a selective RARγ agonist. Growth inhibition by CD437 in these lung cancer cell lines is apparent after 2 days of treatment with 10 μM CD437. Dose-response experiments demonstrate that CD437 reduces the numbers of H460, SK-MES-1, A549, and H292 cells with 50% inhibitory values of approximately 0.5, 0.4, 3, and 0.85 μM, respectively. Treatment for 72 h with CD437 causes a strong dose-dependent growth inhibition in all melanoma cell lines. At a concentration of 5 μM CD437, only about 5 to 25% of the cells remain viable after 3 d. The concentrations of CD437 required for 50% growth inhibition (IC50) range from 10 μM for MeWo to 0.1 μM for SK-Mel-23 showing the highest sensitivity.
In vivo study	Tumors in CD437-treated mice stop growing, an effect that becomes already statistically significant (P<0.01) at day 13, 3 d after first administration of CD437, and is maintained for more than 3 wk after discontinuation of treatment. Further histologic analysis demonstrates marked c-fos mRNA levels at the tumor-stroma edge in CD437-treated tumors.

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
RTECS	QJ1975900

Last Update：2024-01-02 23:10:35

biological activity	CD437 is a selective Retinoic Acid Receptor gamma (RARγ) agonist.
Target	retinotic Acid Receptor gamma (RAR gamma)
in vitro study	CD437 is a selective RAR gamma agonist. Growth inhibition by CD437 in his lung cancer cell lines is significant after 2 days of treatment with 10 μm CD437, and H292 cells with 50% inhibitory values of approval 0.5, 0.4, 3, and 0.85 μM, respectively. Treatment for 72 h with CD437 causes a strong dose-dependent growth inhibition in all melanoma cell lines. At a concentration of 5 μM CD437, only about 5 to 25% of the cells remain viable after 3 d. The concentrations of CD437 required for 50% growth inhibition (IC50) range from 10 μM for MeWo to 0.1 μM for SK-Mel-23 showing the highest sensitivity.
in vivo study	Tumors in CD437-treated mice stop growing, an effect that at day 13, 3 d after first administration of CD437, and is maintained for more than 3 wk after discontinuation of treatment. Further histologic analysis demonstrates marked c-fos mRNA levels at the tumor-stroke edge in CD437-treated tumors.

Last Update：2024-04-09 21:54:55

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CAS: 125316-60-1
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Product Name: CD437 Visit Supplier Webpage Request for quotation
CAS: 125316-60-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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ADAP-IMH

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