AI3-17852
2-Bromopyridine
CAS: 109-04-6
Molecular Formula: C5H4BrN
AI3-17852 - Names and Identifiers
| Name | 2-Bromopyridine |
| Synonyms | NSC 8031 AI3-17852 BRN 0105789 2-Bromopyridine o-Bromopyridine Pyridine,2-bromo- BROMOPYRIDINE(2-) AKOS BBS-00004324 2-Pyridyl bromide beta-Bromopyridine Pyridine, 2-bromo- TIMTEC-BB SBB003999 ALPHA-BROMOPYRIDINE 2-BROMOPYRIDINE FOR SYNTHESIS 5-20-05-00422 (Beilstein Handbook Reference) |
| CAS | 109-04-6 |
| EINECS | 203-641-6 |
| InChI | InChI=1/C5H4BrN/c6-5-3-1-2-4-7-5/h1-4H |
| InChIKey | IMRWILPUOVGIMU-UHFFFAOYSA-N |
AI3-17852 - Physico-chemical Properties
| Molecular Formula | C5H4BrN |
| Molar Mass | 158 |
| Density | 1.657 g/mL at 25 °C (lit.) |
| Melting Point | 193°C |
| Boling Point | 192-194 °C (lit.) |
| Flash Point | 130°F |
| Water Solubility | Slightly miscible with water. |
| Solubility | 20g/l |
| Vapor Presure | 0.784mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear colorless to pale brown |
| BRN | 105789 |
| pKa | pK1: 0.71(+1) (25°C) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Stability | Stable. Flammable. Incompatible with strong oxidizing agents, strong acids, acid chlorides. |
| Refractive Index | n20/D 1.572(lit.) |
| Physical and Chemical Properties | Density 1.65 boiling point 192-194°C refractive index 1.5705-1.5725 flash point 54°C |
| Use | Used as a pharmaceutical Intermediate |
AI3-17852 - Risk and Safety
| Risk Codes | R10 - Flammable R24/25 - R36/37/38 - Irritating to eyes, respiratory system and skin. R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S16 - Keep away from sources of ignition. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S38 - In case of insufficient ventilation, wear suitable respiratory equipment. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S28A - S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 2929 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | US3850000 |
| FLUKA BRAND F CODES | 8 |
| TSCA | Yes |
| HS Code | 29333999 |
| Hazard Note | Toxic |
| Hazard Class | 6.1 |
| Packing Group | II |
AI3-17852 - Upstream Downstream Industry
| Raw Materials | 2-Aminopyridine 2-Aminopyridine Benzene |
AI3-17852 - Reference Information
| LogP | 1.42 |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | organic synthesis, pharmaceutical intermediates. In the pharmaceutical industry for the synthesis of heart disease drugs such as dipyridamole (disopyramide phosphate). used as pharmaceutical intermediates dimethyl sulfate is one of the important chemical raw materials, it is an important methyl agent, in chemical, pharmaceutical, pesticide, military, dyes, spices, rubber |
| production method | is obtained by bromination of 2-aminopyridine. In industrial production, hydrobromic acid (above 48%) is cooled to below 0 ℃, 2-aminopyridine is slowly added, and then liquid bromine is added dropwise under freezing in a salt bath, the rate of addition is preferably controlled at a reaction temperature below -5 °c. After adding sodium nitrite aqueous solution, control the reaction temperature below 0 ℃, stir for 20-30min, Dropwise add 50% sodium hydroxide solution, extract the reaction solution with ether, wash with water, dry with anhydrous sodium sulfate, filter, diethyl ether was recovered, and the residue was distilled under reduced pressure, and fractions of 88 ° C- 94 ° C./3333Pa were collected to obtain the final product in a yield of 83.8%. |
| category | toxic substances |
| toxicity grade | high toxicity |
| Acute toxicity | intraperitoneal-mouse LDL0: 31.3 mg/kg |
| flammability hazard characteristics | toxic NOx and bromide fumes emitted by thermal decomposition |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Stored separately from food raw materials |
| fire extinguishing agent | foam, dry powder, carbon dioxide, water mist |
Last Update：2024-04-09 02:00:04
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Raw Materials for AI3-17852