ALPHA-CYANO-(3,5-DI-T-BUTYL-4-HYDROXY)THIOCINNAMIDE
Tyrphostin AG 879
CAS: 148741-30-4
Molecular Formula: C18H24N2OS
ALPHA-CYANO-(3,5-DI-T-BUTYL-4-HYDROXY)THIOCINNAMIDE - Names and Identifiers
ALPHA-CYANO-(3,5-DI-T-BUTYL-4-HYDROXY)THIOCINNAMIDE - Physico-chemical Properties
| Molecular Formula | C18H24N2OS |
| Molar Mass | 316.46 |
| Solubility | DMSO: at 26 mg/mlsoluble |
| Appearance | Orange-yellow solid |
| Color | Yellow |
| Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| Stability | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| MDL | MFCD00236450 |
| Physical and Chemical Properties | Yellow powder, soluble in DMSO (up to 100 mM). |
| Use | Tyrphostin AG 879 |
| In vitro study | AG879 inhibited the growth of FET6αS26X cells in a concentration-dependent manner. AG879(10 nM) blocks the activation of PAK1 and inhibits RAS-induced carcinogenesis of NIH 3T3 cells. AG879(<1 μm) inhibited Tyr phosphorylation of ERK and Association of ERK with PAK1 in transformed NIH 3T3 fibroblasts by v-Ha-RAS. AG 879 dose-dependently reduced MCF-7 cell number and has shown a significant effect at 0.4 mM by inhibiting DNA synthesis and mitosis. AG 879(<20 μm) inhibited MCF-7/2 activation in ERK-1 cells. AG 879(5 μm) reduced the expression of Hsp90 client protein RAF-1 and HER-2. In human leiomyosarcoma (HTB-114,HTB-115,HTB-88), rhabdomyosarcoma (HTB-82,TE-671), prostate cancer (PC-3), acute promyelocytic leukemia (HL-60) and histiocytic lymphoma (U-937) in cell lines, AG879(20 μm) significantly reduced cell proliferation and increased apoptosis to varying degrees. |
| In vivo study | AG879(2 mg) reduced tumor growth in HTB-114 or HL-60 athymic NOD/SCID mice transplanted. In nude mice harboring v-Ha-RAS transformed NIH 3T3 cells, AG 879(20 mg/kg) treatment completely protected 50% of mice from RAS-Induced Sarcoma and significantly reduced the size of the growing sarcoma. |
ALPHA-CYANO-(3,5-DI-T-BUTYL-4-HYDROXY)THIOCINNAMIDE - Risk and Safety
| WGK Germany | 3 |
| HS Code | 29309090 |
ALPHA-CYANO-(3,5-DI-T-BUTYL-4-HYDROXY)THIOCINNAMIDE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.16 ml | 15.8 ml | 31.6 ml |
| 5 mM | 0.632 ml | 3.16 ml | 6.32 ml |
| 10 mM | 0.316 ml | 1.58 ml | 3.16 ml |
| 5 mM | 0.063 ml | 0.316 ml | 0.632 ml |
Last Update：2024-01-02 23:10:35
ALPHA-CYANO-(3,5-DI-T-BUTYL-4-HYDROXY)THIOCINNAMIDE - Introduction
Tyrphostin AG 879 is a tyrosine kinase inhibitor and a tyrosine kinase receptor inhibitor. It has structural characteristics and can inhibit the activity of a variety of tyrosine kinases.
Tyrphostin AG 879 is mainly used in biochemical and pharmacological research, especially in cancer treatment research. It can inhibit the growth and proliferation of tumor cells, and then inhibit the metastasis and invasion of cancer cells.
The preparation method of Tyrphostin AG 879 is synthesized by synthetic organic chemistry method. The specific preparation method can refer to the relevant research literature or patent.
Regarding the safety information of Tyrphostin AG 879, it is a chemical reagent and needs to be used in accordance with safe operating regulations. During the operation should avoid direct contact with the skin and eyes, if accidentally contact, should immediately rinse with plenty of water. At the same time, it should be operated in a well-ventilated laboratory environment and stored properly. During use, care should be taken to prevent it from being inhaled or accidentally eaten, so as not to cause harm to health.
Tyrphostin AG 879 is mainly used in biochemical and pharmacological research, especially in cancer treatment research. It can inhibit the growth and proliferation of tumor cells, and then inhibit the metastasis and invasion of cancer cells.
The preparation method of Tyrphostin AG 879 is synthesized by synthetic organic chemistry method. The specific preparation method can refer to the relevant research literature or patent.
Regarding the safety information of Tyrphostin AG 879, it is a chemical reagent and needs to be used in accordance with safe operating regulations. During the operation should avoid direct contact with the skin and eyes, if accidentally contact, should immediately rinse with plenty of water. At the same time, it should be operated in a well-ventilated laboratory environment and stored properly. During use, care should be taken to prevent it from being inhaled or accidentally eaten, so as not to cause harm to health.
Last Update：2024-04-09 21:54:55
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Spot supply
Product Name: Tyrphostin AG 879 Visit Supplier Webpage Request for quotationCAS: 148741-30-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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