AM-630

Name	AM 630
Synonyms	AM630 AM 630 AM-630 SC-200365(AM-630) Iodopravadoline (AM630) 1-[2-(Morpholin-4-yl)ethyl]-2-Methyl-3-(4-Methoxybenzoyl)-6-iodoindole (6-iodo-2-Methyl-1-(2-Morpholinoethyl)-1H-indol-3-yl)(4-Methoxyphenyl)Methanone 6-IODO-2-METHYL-1-[[2-(4-MORPHOLINYL)ETHYL]-1H-INDOL-3-YL](4-METHOXYPHENYL)METHANONE Methanone, [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)-
CAS	164178-33-0

Molecular Formula	C23H25IN2O3
Molar Mass	504.36
Density	1.49±0.1 g/cm3(Predicted)
Boling Point	605.9±55.0 °C(Predicted)
Solubility	DMSO: >5mg/mL
Appearance	powder
Color	white to beige
pKa	6.98±0.10(Predicted)
Storage Condition	2-8°C
In vitro study	The AM251 and 6-Iodopravadoline (AM630)-evoked Ca 2+ influxes into TG sensory neurons aere concentration-dependent, and fitted. The EC 50 for AM251 and 6-Iodopravadoline are 7.37 μM and 15.6 μM, respectively. AM251 and 6-Iodopravadoline activate TRPA1 in TG sensory neurons. 6-Iodopravadoline is comparable in value in both TRPA1 and TRPV1/TRPA1 expressing CHO cells (2 and 4.6 μM, respectively). AM251 and 6-Iodopravadoline activation of TRPA1 is modulated by TRPV1. 6-Iodopravadoline (0, 50, 100, and 200 nM) is not toxic to RAW264.7 cells. 6-Iodopravadoline (100 nM) substantially inhibits osteoclastogenesis in cultures with RANKL and Ti particles in a dose-dependent manner. 6-Iodopravadoline (1 μM) blocks the CP-55,940 dose response with EC 50 of 170 nM at human and EC 50 of 110 nM at rat cannabinoid CB2 receptor.
In vivo study	6-Iodopravadoline (AM630) (2, 3 mg/kg, i.p.) significantly reduces the time spent in the light box compared with vehicle group. 6-Iodopravadoline (AM630) (1, 2 or 3 mg/kg, i.p., twice a day) produces a significant anxiolytic effect, increasing the time spent in the light box at all of the doses used.

Hazard Symbols	N - Dangerous for the environment
Risk Codes	50 - Very Toxic to aquatic organisms
Safety Description	61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
UN IDs	UN 3077 9 / PGIII
WGK Germany	3

Last Update：2024-01-02 23:10:35

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Product Name: AM 630 Visit Supplier Webpage Request for quotation
CAS: 164178-33-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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AM-630

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