Name | AM095 |
Synonyms | AM095 AM-095 AM 095 CS-1624 AM-095 FREE ACID AM 095 FREE ACID AM095 (free acid) AM-095 (free base) AM 095 (parent compound) [4'-[3-Methyl-4-[[[((R)-1-phenylethyl)oxy]carbonyl]amino]isoxazol-5-yl]biphenyl-4-yl]acetic acid 2-[4-[4-[3-methyl-4-[[(1r)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic Acid [1,1'-Biphenyl]-4-acetic acid, 4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]- |
CAS | 1228690-36-5 |
Molecular Formula | C27H24N2O5 |
Molar Mass | 456.49 |
Density | 1.278±0.06 g/cm3(Predicted) |
Boling Point | 641.9±55.0 °C(Predicted) |
Solubility | DMSO: 67.3 mg/mL |
pKa | 4.21±0.10(Predicted) |
Storage Condition | -20℃ |
Physical and Chemical Properties | Bioactive AM095 is an antagonist of LPA1 receptor. The IC50 for human-derived recombinant LPA1 and mouse LPA1 is 0.98 μM and 0.73 μM respectively. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.191 ml | 10.953 ml | 21.906 ml |
5 mM | 0.438 ml | 2.191 ml | 4.381 ml |
10 mM | 0.219 ml | 1.095 ml | 2.191 ml |
5 mM | 0.044 ml | 0.219 ml | 0.438 ml |
acidity coefficient (pKa) | 4.21±0.10(Predicted) |
biological activity | AM095 is an antagonist of LPA1 receptor, and its IC50 for human recombinant LPA1 and mouse LPA1 is 0.98 μM and 0.73 μM respectively. |
target | TargetValue LPA1 receptor () |
Target | Value |