Name | AM-2394 |
Synonyms | AM2394 AM 2394 AM-2394 CS-2242 N-[6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methylurea 1-(6'-(2-hydroxy-2-methylpropoxy)-4-((5-methylpyridin-3-yl)oxy)-[3,3'-bipyridin]-6-yl)-3-methylurea Urea, N-[6'-(2-hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methyl- |
CAS | 1442684-77-6 |
Molecular Formula | C22H25N5O4 |
Molar Mass | 423.46 |
Density | 1.266±0.06 g/cm3(Predicted) |
Boling Point | 588.8±50.0 °C(Predicted) |
Solubility | DMSO: ≥ 30 mg/mL |
pKa | 12.66±0.70(Predicted) |
Storage Condition | Inert atmosphere,Room Temperature |
In vivo study | AM-2394, a structurally distinct glucokinase activator that displays a robust reduction in plasma glucose during an oral glucose tolerance test (OGTT) in ob/ob mice at a dose of 3 mg/kg. AM-2394 increases the affinity of glucokinase (GK) for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. AM-2394 exhibits good-to-moderate cross species plasma clearance, volume of distribution, and oral bioavailability, allowing for further evaluation in animal models. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.361 ml | 11.807 ml | 23.615 ml |
5 mM | 0.472 ml | 2.361 ml | 4.723 ml |
10 mM | 0.236 ml | 1.181 ml | 2.361 ml |
5 mM | 0.047 ml | 0.236 ml | 0.472 ml |
use | AM 2394 is a unique glucokinase activator (GKA). AM-2394 activates GK through an EC50 of 60 nM. |
biological activity | AM-2394 is a new type of glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with EC50 of 60 nM. |
target | EC50: 60 nM (glucokinase) |
in vivo research | AM-2394, A structurally distinct glucokinase activator that displays a robust reduction in plasma glucose during an oral glucose tolerance test (OGTT) in ob/ob mice at a dose of 3 mg/kg. AM-2394 increases the affinity of glucokinase (GK) for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animation models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. am -2394 exhibits good-to-moderate cross species plasma clearance, volume of distribution, and oral bioavailability, allowing for further evaluation in animation models. |