Molecular Formula | C29H28F3N5O2 |
Molar Mass | 535.56 |
Density | 1.324 |
pKa | 13.23±0.70(Predicted) |
Storage Condition | 2-8 ℃, dark |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.867 ml | 9.336 ml | 18.672 ml |
5 mM | 0.373 ml | 1.867 ml | 3.734 ml |
10 mM | 0.187 ml | 0.934 ml | 1.867 ml |
5 mM | 0.037 ml | 0.187 ml | 0.373 ml |
biological activity | AMG-47a is an effective and non-selective Lck kinase inhibitor, IC50 is 3.4 uM, it can also inhibit T cell proliferation. AMG-47a exhibited 11 mg/kg anti-inflammatory activity (ED50) during anti-CD3-induced production of mouse interleukin-2 (IL-2). |
target | TargetValue LCK (Cell-free say) 3.4 μM |
Target | Value |
LCK (Cell-free assay) | 3.4 μM |