APX-115
APX-115
CAS: 1395946-75-4
Molecular Formula: C17H18ClN3O
APX-115 - Names and Identifiers
| Name | APX-115 |
| Synonyms | APX-115 Ewha-18278 |
| CAS | 1395946-75-4 |
APX-115 - Physico-chemical Properties
| Molecular Formula | C17H18ClN3O |
| Molar Mass | 315.8 |
| Storage Condition | -20°C，密封，干燥 |
| In vitro study | APX-115 (5 μM; 60 min) almost completely suppresses high glucose-induced proinflammatory and profibrotic molecule expression in the mouse podocyte cell line. In the kidney, APX-115 attenuates Nox gene upregulation and protein expression while improving inflammatory and fibrotic processes. |
| In vivo study | APX-115 (oral gavage; 60 mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice. APX-115 treatment decreases the urinary excretion of albumin and plasma creatinine levels. Animal Model: Six-week-old male diabetic db/db mice (C57BLKS/J- lepr db /lepr db ) Dosage: 60 mg/kg Administration: Oral gavage; per day; for 12 weeks Result: Significantly improved insulin resistance in diabetic mice. |
