ARV-771

Name	ARV-771
Synonyms	ARV 771 ARV-771 ARV771 (2S,4R)-1-[(2S)-2-[[2-[3-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3- (2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide (2S,4R)-1-[(2S)-2-[[2-[3-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
CAS	1949837-12-0

Molecular Formula	C49H60ClN9O7S2
Molar Mass	986.65
Density	1.39±0.1 g/cm3(Predicted)
Solubility	10 mM in DMSO
pKa	13.61±0.46(Predicted)
Storage Condition	Sealed in dry,Store in freezer, under -20°C

Last Update：2024-01-02 23:10:35

biological activity	ARV-771 is an effective pan-(bromodomain and extra-terminal)BET degradation agent, A new BET-PROTAC (protein-targeting chimera), for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1) and BRD4(2) have Kd values of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM, respectively.
Target	Value
BRD2-BD2 (Cell-free assay)	4.7 nM(Kd)
BRD3-BD2 (Cell-free assay)	7.6 nM(Kd)
BRD4-BD2 (Cell-free assay)	7.6 nM(Kd)
BRD3-BD1 (Cell-free assay)	8.3 nM(Kd)
BRD4-BD1 (Cell-free assay)	9.6 nM(Kd)
Use	an effective BET degradant of the PROTAC class.

Last Update：2024-04-10 22:29:15

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CAS: 1949837-12-0
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Product Name: ARV-771 Visit Supplier Webpage Request for quotation
CAS: 1949837-12-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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ARV-771

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