AS605240
(Z)-5-(quinoxalin-6-ylmethylene)thiazolidine-2,4-dione
CAS: 648450-29-7
Molecular Formula: C12H7N3O2S
AS605240 - Names and Identifiers
AS605240 - Physico-chemical Properties
| Molecular Formula | C12H7N3O2S |
| Molar Mass | 257.27 |
| Density | 1.553±0.06 g/cm3(Predicted) |
| Solubility | DMSO: soluble1mg/mL, clear (warmed) |
| Appearance | powder |
| Color | , faint red to orange to dark brown |
| pKa | 6.02±0.20(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD11100415 |
| Use | AS605240 |
| In vitro study | AS-605240 inhibits PI3Kγ with an IC50 of 8 nM. AS-605240 is an ATP-competitive inhibitor of PI3Kγ with a Ki value of 7.8 nM. AS-605240 also inhibited PI3Kα,β, and δ, with IC50 values of 60,270, and 300 nM, respectively. AS-605240 inhibits c5a-mediated phosphorylation of PKB with an IC50 of 90 nM. 1 μm AS-605240 inhibited MCP-1 or CSF-1 of PKB phosphorylation induced by bone marrow mononuclear cells (BMDMs). 100 nM AS-605240 acts on the SC-CA1 synapse in the mouse, eliminating NMDAR LTD, without affecting mGluR LTD, and LTP. |
| In vivo study | AS-605240 reduced neutrophil chemotaxis in a RANTES-induced murine model of peritonitis with an ED50 of 9.1 mg/kg. AS-605240 acts at a dose of 50 mg/kg on αcii-induced arthritis and protects it from αcii-IA symptoms. AS-605240 at a dose of 50 mg/kg also inhibited joint inflammation and injury in a collagen-induced arthritis mouse model. AS-605240 at a dose of 10 mg/kg in ob/ob mouse model of obesity-induced diabetes reduced blood glucose levels, significantly improved insulin sensitivity and glucose tolerance, and did not affect body weight. AS-605240 treatment at a dose of 30 mg/kg showed a better effect with only a slight effect on body weight. Moreover, AS-605240 reduced the amount of ATS and circulating levels MCP-1. |
AS605240 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
AS605240 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.887 ml | 19.435 ml | 38.87 ml |
| 5 mM | 0.777 ml | 3.887 ml | 7.774 ml |
| 10 mM | 0.389 ml | 1.943 ml | 3.887 ml |
| 5 mM | 0.078 ml | 0.389 ml | 0.777 ml |
Last Update：2024-01-02 23:10:35
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CAS: 648450-29-7
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CAS: 648450-29-7
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Product Name: (Z)-5-(quinoxalin-6-ylmethylene)thiazolidine-2,4-dione Visit Supplier Webpage Request for quotation
CAS: 648450-29-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 648450-29-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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