Molecular Formula | C18H22N4O2 |
Molar Mass | 326.39 |
Solubility | DMSO: ≥ 60 mg/mL |
Storage Condition | -20℃ |
In vitro study | ASP015K inhibits IL-2-induced proliferation of human T cells with higher potency than EPO-induced proliferation of human erythroleukemia cells. In human whole blood, ASP015K inhibits STAT5 phosphorylation (pSTAT5). |
In vivo study | In the rat model of AIA, ASP015K (p.o.) significantly reduced foot swelling and the probability of ankle bone destruction. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.064 ml | 15.319 ml | 30.638 ml |
5 mM | 0.613 ml | 3.064 ml | 6.128 ml |
10 mM | 0.306 ml | 1.532 ml | 3.064 ml |
5 mM | 0.061 ml | 0.306 ml | 0.613 ml |