AT-TMA

AT-TMA - Names and Identifiers

Name	( Z )-2-(2-Aminothiazol-4-yl)-2-(t-butoxycarbonylmethoxyimino)acetic acid
Synonyms	ATTMA AT-TMA ASTRAGALUSROOTRGBRM (2-AMINOTHIAZOL-4-YL)-TERT-BUTOXYCARBONYLMETHOXYIMINO ACETIC ACID ( Z )-2-(2-Aminothiazol-4-yl)-2-(t-butoxycarbonylmethoxyimino)acetic acid (Z)-2-(2-Aminothiazol-4-Yl)-2-(Tert-Butoxycarbonylmethoxyimino)Acetic Acid (Z)-2-(2-Aminothiazol-4-yl)-2-(tert-butoxycarbonylmethoxyimino)acetic acid (2Z)-(2-amino-1,3-thiazol-4-yl)[(2-tert-butoxy-2-oxoethoxy)imino]ethanoic acid (aZ)-2-Amino-α-[[2-(1,1-dimethylethoxy)-2-oxoethoxy]imino]-4-thiazoleacetic Acid (aZ)-2-Amino-a-[[2-(1,1-dimethylethoxy)-2-oxoethoxy]imino]-4-thiazoleacetic Acid (Z)-2-(2-aminothiazol-4-yl)-2-t-butoxycarbonyl methoxyimino) acetic Acid (AT-TMA or TBCA)
CAS	74440-02-1
InChI	InChI=1/C11H15N3O5S/c1-11(2,3)19-7(15)4-18-14-8(9(16)17)6-5-20-10(12)13-6/h5H,4H2,1-3H3,(H2,12,13)(H,16,17)/b14-8-

AT-TMA - Physico-chemical Properties

Molecular Formula	C11H15N3O5S
Molar Mass	301.32
Density	1.43±0.1 g/cm3(Predicted)
Melting Point	175-176 °C (decomp)
Boling Point	482.8±51.0 °C(Predicted)
Flash Point	245.8°C
Solubility	DMSO, Methanol (Sparingly)
Vapor Presure	3.93E-10mmHg at 25°C
Appearance	Solid
Color	White to Off-White
pKa	2?+-.0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.601

AT-TMA - Introduction

(Z )-2-(2-Aminothiazol-4-yl)-2-(t-butoxycarbonylmethoxyimino)acetic acid is a compound with the formula C11H15N3O4S. Here are some properties and information about the compound:

Nature:
-Appearance: Colorless or light yellow crystalline powder
-Solubility: Slightly soluble in water
-melting point: about 135-140 ℃
-Molecular weight: 285.32g/mol
-Possible stereoisomers, of which (Z)-form is the dominant isomer

Use:
- ( Z )-2-(2-Aminothiazol-4-yl)-2-(t-butoxycarbonylmethoxyimino)acetic acid is a commonly used intermediate compound, often used in organic synthesis reactions.
-It can be used to synthesize other aminothiazole derivatives.

Preparation Method:
the synthesis method of (Z )-2-(2-Aminothiazol-4-yl)-2-(t-butoxycarbonylmethoxyimino)acetic acid is relatively complicated, and the commonly used methods include the following steps:
1. First, 2-aminothiazol-4-ol and dimethylmethyleneamine undergo an amidation reaction to generate 2-(2-aminothiazol-4-yl) acetamide.
2. Next, 2-(2-aminothiazol-4-yl) acetamide is reacted with tert-butoxycarbonylketone to produce 2-(2-aminothiazol-4-yl)-2-tert-butoxycarbonylacetic acid.
3. finally, the obtained compound is reacted with sodium carbonyldiazenecarboxylate to obtain (Z )-2-(2-Aminothiazol-4-yl)-2-(t-butoxycarbonylmethoxyimino)acetic acid.

Safety Information:
There is limited information regarding the safety of (Z )-2-(2-Aminothiazol-4-yl)-2-(t-butoxycarbonylmethoxyimino)acetic acid. As a chemical substance, attention should be paid to its possible harm to the human body. Maintain proper precautions during handling and storage. Detailed safety information should refer to the safety data sheet (SDS) of the relevant chemical. When using this compound, please observe the correct experimental practice.

Last Update：2024-04-10 22:29:15