Name | 1-(2,6-Diisopropylphenyl)-3-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea |
Synonyms | ATR 101 ATR101 ATR-101 PD-132301 Nevanimibe PD-132301 1-(2,6-Diisopropylphenyl)-3-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea N-(2,6-bis(isopropyl)phenyl)-N'-((1-(4-(dimethylaminomethyl)phenyl)cyclopentyl)methyl)urea Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[1-[4-(dimethylamino)phenyl]cyclopentyl]methyl]- |
CAS | 133825-80-6 |
Molecular Formula | C27H39N3O |
Molar Mass | 421.62 |
Density | 1.062±0.06 g/cm3(Predicted) |
Boling Point | 528.1±50.0 °C(Predicted) |
pKa | 13.91±0.46(Predicted) |
Storage Condition | 2-8°C |
Use | Nevanimibe (PD-132301) is an orally effective, selective acyl-CoA: cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe inhibited ACAT2 and EC50 was 368 nM. Nevanimibe induces apoptosis (apoptosis) and has the potential to resist adrenocortical carcinoma. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.372 ml | 11.859 ml | 23.718 ml |
5 mM | 0.474 ml | 2.372 ml | 4.744 ml |
10 mM | 0.237 ml | 1.186 ml | 2.372 ml |
5 mM | 0.047 ml | 0.237 ml | 0.474 ml |