AZ-191

Name	AZ191
Synonyms	AZ191 AZ 191 AZ-191 CS-1824 N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine 2-Pyrimidinamine, N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)- [2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenyl]-[4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-pyrimidin-2-yl]-amine N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine, AZ191
CAS	1594092-37-1

Molecular Formula	C24H27N7O
Molar Mass	429.52
Density	1.29±0.1 g/cm3(Predicted)
Boling Point	705.3±70.0 °C(Predicted)
Solubility	DMSO: soluble10mg/mL, clear
Appearance	powder
Color	, white to yellow to light brown
pKa	7.76±0.42(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
In vitro study	AZ191 (0.01-60μM; 5 days) inhibits SW872 and SW982 cell lines in dose-dependent manner with IC 50 s of 3.183 μM and 1.279 μM, respectively. AZ191 (1-5 μM; 48 hours) down-regulates three anti-apoptotic proteins (Bcl-2, p21, and survivin) at higher concentrations. Cell Proliferation Assay Cell Line: SW872, SW982 liposarcoma cells Concentration: 0.01, 0.03, 0.1, 0.3, 0.6, 1, 3, 6, 10, 20, 60 μM Incubation Time: 5 days Result: Dose-dependent growth inhibition with IC 50 s of 3.183 μM and 1.279 μM for SW872 and SW982 cell lines, respectively. Western Blot Analysis Cell Line: SW872, SW982 liposarcoma cells Concentration: 1, 2, 3, 4, 5 μM Incubation Time: 48 hours Result: Down-regulated three anti-apoptotic proteins (Bcl-2, p21, and survivin) at higher concentrations.

WGK Germany

Last Update：2024-01-02 23:10:35

biological activity	AZ191 is a highly selective inhibitor of DYRK1B with an IC50 value of 17 nM.
target	IC50: 17 nM (DYRK1B)
in vitro study	AZ191 (0.01-60 μ M; 5 days) inhibits SW872 and SW982 cell lines in dose-dependent manner with IC 50 s of 3.183 μ m and 1.279 μ m, respectively. AZ191 (1-5 μ m; 48 hours) down-regulates three anti-apoptotic proteins (Bcl-2, p21, and survivin) at higher concentrations. cell Proliferation Assay Cell Line: SW872, SW982 liposarcoma cells Concentration: 0.01, 0.03, 0.1, 0.3, 0.6, 1, 3, 6, 10, 20, 60 μ m Incubation time: 5 days result: dose-dependent growth inhibition with IC 50 s of 3.183 μ m and 1.279 μ m for SW872 and SW982 cell lines, respectively. Western Blot Analysis Cell Line: SW872, SW982 liposarcoma cells Concentration: 1, 2, 3, 4, 5 μ m Incubation time: 48 hours result: down-regulated three anti-apoptotic proteins (Bcl-2, p21, and survivin) at higher concentrations.
Cell Line:	SW872, SW982 liposarcoma cells SW872, SW982 liposarcoma cells
Concentration:	0.01, 0.03, 0.1, 0.3, 0.6, 1, 3, 6, 10, 20, 60 μM 1, 2, 3, 4, 5 μM
Incubation Time:	5 days 48 hours
Result:	Dose-dependent growth inhibition with IC 50 s of 3.183 μM and 1.279 μM for SW872 and SW982 cell lines, respectively. Down-regulated three anti-apoptotic proteins (Bcl-2, p21, and survivin) at higher concentrations.

Last Update：2024-04-09 21:54:55

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CAS: 1594092-37-1
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Product Name: AZ191 Visit Supplier Webpage Request for quotation
CAS: 1594092-37-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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AZ-191

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