AZD1152-HQPA(Barasertib)
Barasertib (AZD1152-HQPA)
CAS: 722544-51-6
Molecular Formula: C26H30FN7O3
AZD1152-HQPA(Barasertib) - Names and Identifiers
AZD1152-HQPA(Barasertib) - Physico-chemical Properties
| Molecular Formula | C26H30FN7O3 |
| Molar Mass | 507.56 |
| Density | 1.359±0.06 g/cm3(Predicted) |
| Boling Point | 796.7±60.0 °C(Predicted) |
| Solubility | DMSO: >15mg/mL |
| Appearance | powder |
| Color | white to beige |
| pKa | 13.07±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| MDL | MFCD10687152 |
| Use | AZD1152-HQPA |
| In vitro study | AZD1152 acts on Aurora B more than 3000 times more selective than Aurora A, IC50 is 1.368 μm. AZD1152 acts on 50 other serine-threonine and tyrosine kinases, including FLT3, JAK2, and Abl with lower activity. AZD1152 inhibits the proliferation of hematopoietic malignant cells, such as HL-60, NB4, MOLM13, PALL-1, PALL-2, MV4-11, EOL-1, THP-1, and K562 cells, with an IC50 of 3-40 nM, the effect is more than 100 times higher than that of another Aurora kinase inhibitor, ZM334739, with an IC50 of 3-30 μm. AZD1152 inhibited the growth of MOLM13 and MV4-11 cell clones with IC50 of 1 nM and 2.8 nM, respectively, and also inhibited newly isolated leukemic cells resistant to Imatinib with IC50 of 1-3 nM, more effective than on bone marrow mononuclear cells, IC50>10 nM. AZD1152 induced accumulation of cells carrying 4N/8N DNA followed by apoptosis in a dose-and time-dependent manner. |
| In vivo study | AZD1152 treated MOLM13 xenografts alone at a dose of 25 mg/kg significantly inhibited tumor growth, with an average tumor volume from 1261mm, treatment of AZD1152 at doses of 10-150 mg/kg per day in a variety of solid human xenografts, including colon, breast, and lung cancers, significantly inhibited tumor growth in a dose-dependent manner. |
AZD1152-HQPA(Barasertib) - Risk and Safety
| WGK Germany | 3 |
AZD1152-HQPA(Barasertib) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.97 ml | 9.851 ml | 19.702 ml |
| 5 mM | 0.394 ml | 1.97 ml | 3.94 ml |
| 10 mM | 0.197 ml | 0.985 ml | 1.97 ml |
| 5 mM | 0.039 ml | 0.197 ml | 0.394 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: AZD1152-HQPA Visit Supplier Webpage Request for quotationCAS: 722544-51-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Barasertib (AZD1152-HQPA) Visit Supplier Webpage Request for quotationCAS: 722544-51-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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