AZD2014(Vistusertib)

AZD2014(Vistusertib) - Names and Identifiers

Name	3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide
Synonyms	AZD2014 AZD2014(Vistusertib) 3-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-N-methylbenzamide 3-{2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl}-N-methylbenzamide 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide AZD2014 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide AZD2014
CAS	1009298-59-2

AZD2014(Vistusertib) - Physico-chemical Properties

Molecular Formula	C19H17ClN2O3S
Molar Mass	388.87
Density	1.231
Melting Point	233-237oC
Water Solubility	Chloroform (Slightly), Methanol (Slightly)
Solubility	DMSO 11 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Appearance	Shape Solid Color Light Yellow
pKa	14.45±0.46(Predicted)
Storage Condition	-20°C Freezer
Use	AZD2014 is a new mTOR inhibitor with IC50 of 2.8 nM. Highly selective action on various PI3K subtypes (α/β/γ/δ).

AZD2014(Vistusertib) - Risk and Safety

HS Code

29339900

AZD2014(Vistusertib) - Introduction

AZD1981 is an effective, selective CRTh2 (DP2) receptor antagonist with an IC50 of 4 nM, which is more than 1000 times more selective than acting on 340 other enzymes and receptors (including DP1).

Last Update：2022-10-16 17:30:56

AZD2014(Vistusertib) - Biological activity

Vistusertib (AZD2014) is a new type of mTOR inhibitor, IC50 is 2.8 nM in cell-free test; It has high selectivity for various PI3K subtypes (α/β/& gamma;/& delta;). At a concentration of 1 μM, there is no or weak binding force for most kinases. AZD2014 can induce proliferation inhibition, apoptosis, cell cycle arrest and autophagy in HCC cells, and has anti-tumor activity.

Last Update：2024-04-09 20:48:19