AZILSARTAN
Azilsartan
CAS: 147403-03-0
Molecular Formula: C25H20N4O5
AZILSARTAN - Names and Identifiers
| Name | Azilsartan |
| Synonyms | CS-865 AZATMint-E Azilsartan AZILSARTAN 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid 2-Ethoxy-1-{[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid Azilsartan 2-ethoxy -1- {[2'-(5-oxo-4,5-dihydro -1,2,4 -oxadiazol-3-yl) biphenyl-4-yl ] methyl} -1H –benzimi[d]dazole-7-carboxylic acid 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro- 1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid |
| CAS | 147403-03-0 |
| EINECS | 808-058-6 |
| InChIKey | KGSXMPPBFPAXLY-UHFFFAOYSA-N |
AZILSARTAN - Physico-chemical Properties
| Molecular Formula | C25H20N4O5 |
| Molar Mass | 456.45 |
| Density | 1.42 |
| Melting Point | 188 °C(dec.) |
| Solubility | DMSO: soluble15mg/mL (clear solution) |
| Appearance | powder |
| Color | white to beige |
| pKa | 2.05±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| MDL | MFCD00916395 |
| In vitro study | Azilsartan inhibits the increase in plasma glucose levels in the oral glucose tolerance test (OGTT),Azilsartan inhibits the increase in plasma glucose levels without significantly altering insulin concentrations or increasing insulin sensitivity. In skeletal muscle, the 0.001% dose of Azilsartan reduced the expression of TNF-α. In adipose tissue, Azilsartan decreased TNF-α expression, but increased adiponectin, PPARγ,C/ebα, and AP2. Azilsartan enhances adipogenesis in cultured 3T3-L1 preadipocytes, acting on the genes encoding peroxisome proliferator-activated receptor-α (PPARα),PPAR δ, leptin, lipase, and the expression of adiponectin, more effective than valsartan. Azilsartan also effectively inhibited vascular cell proliferation in the absence of exogenous supplemented angiotensin II. |
| In vivo study | In Koletsky rats, Azilsartan treatment reduces blood pressure, basal plasma insulin concentration and homeostasis Pattern Assessment of insulin resistance index, and inhibits excessive increases in blood glucose and insulin concentration in the oral glucose tolerance test. Azilsartan down-regulates the expression of 11 β-hydroxysteroid dehydrogenase type 1. |
AZILSARTAN - Risk and Safety
| WGK Germany | 3 |
Supplier List
Spot supply
Product Name: Azilsartan Visit Supplier Webpage Request for quotationCAS: 147403-03-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Azilsartan Visit Supplier Webpage Request for quotationCAS: 147403-03-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Azilsartan Request for quotation
CAS: 147403-03-0
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302
Product List: View Catalog
CAS: 147403-03-0
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302
Product List: View Catalog
Spot supply
Product Name: Azilsartan Visit Supplier Webpage Request for quotationCAS: 147403-03-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Azilsartan Visit Supplier Webpage Request for quotationCAS: 147403-03-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Azilsartan Request for quotation
CAS: 147403-03-0
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302
Product List: View Catalog
CAS: 147403-03-0
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302
Product List: View Catalog
View History