Ac-muramyl-Ala-D-Glu-NH
Muramyl Dipeptide
CAS: 53678-77-6
Molecular Formula: C19H32N4O11
Ac-muramyl-Ala-D-Glu-NH - Names and Identifiers
Ac-muramyl-Ala-D-Glu-NH - Physico-chemical Properties
| Molecular Formula | C19H32N4O11 |
| Molar Mass | 492.48 |
| Density | 1.390±0.06 g/cm3(Predicted) |
| Boling Point | 1071.8±65.0 °C(Predicted) |
| Solubility | H2O: 10 mg/mL, clear, colorless |
| Appearance | buffered aqueous solution |
| Merck | 13,6329 |
| BRN | 4220745 |
| pKa | 4.44±0.10(Predicted) |
| Storage Condition | -20°C |
| Physical and Chemical Properties | Bioactive Muramyl dipeptide (MDP) is a common structural unit of peptidoglycan. Muramyl dipeptide induce bone formation by inducing Runx2. |
| Use | Uses Adjuvant peptides are mainly used in the fields of medicine and chemical industry. |
Ac-muramyl-Ala-D-Glu-NH - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | MA2275260 |
| FLUKA BRAND F CODES | 10 |
Ac-muramyl-Ala-D-Glu-NH - Uses and synthesis methods
overview
Adjuvant peptide refers to a peptide that promotes or modulates the function of an antigen by inducing, enhancing and/or promoting an immune response against the antigen as a functional component (in the composition).
Target
Target Value
Runx2
in vitro studies
Muramyl dipeptide (0.1-10 µg/mL; 24 hours) increases protein expression of Runx2 in a dose-dependent manner.
Muramyl dipeptide (0.1-10 µg/mL; 6 hours) increases mRNA levels of Runx2 in a dose-dependent manner.
Western Blot Analysis
Cell Line: MC3T3-E1 cells
Concentration: 0.1, 1, 10 µg/mL
Incubation Time: 24 hours
Result: Increased protein expression of Runx2 in a dose-dependent manner.
RT-PCR
Cell Line: MC3T3-E1 cells
Concentration: 0.1, 1, 10 µg/mL
Incubation Time: 6 hours
Result: Increases mRNA levels of Runx2 in a dose-dependent manner.
In vivo studies
Muramyl dipeptide (1.25 mg/kg; I .p.; twice) alleviates bone loss induced by osteoporosis.
Animal Model: RANKL-induced osteoporosis model (Five-week-old C57BL/6 mice)
Dosage: 1.25 mg/kg
Administration: I .p.; twice (RANKL-induced osteoporosis for 3 weeks and euthanized at 4 weeks)
Result: Significantly enhanced the trabecular bone volume (BV/ TV) and trabecular number (Tb.N).
Last Update：2024-04-10 22:29:15
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Product Name: N-Acetylmuramyl-L-Alanyl-D-Isoglutamine Visit Supplier Webpage Request for quotation
CAS: 53678-77-6
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
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CAS: 53678-77-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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