Adaphostin
Adaphostin
CAS: 241127-58-2
Molecular Formula: C24H27NO4
Adaphostin - Names and Identifiers
Adaphostin - Physico-chemical Properties
| Molecular Formula | C24H27NO4 |
| Molar Mass | 393.48 |
| Solubility | Soluble in DMSO |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | Desiccate at +4°C |
| Use | Adaphostin is a novel activator of Fas-mediated death pathway in Bcr/Abl-positive leukaemia. |
Adaphostin - Risk and Safety
| WGK Germany | 3 |
Adaphostin - Reference
| Reference Show more | 1: Rivera-Del Valle N, Cheng T, Irwin ME, Donnella H, Singh MM, Chandra J. Combinatorial effects of histone deacetylase inhibitors (HDACi), vorinostat and entinostat, and adaphostin are characterized by distinct redox alterations. Cancer Chemother Pharmacol. 2018 Mar;81(3):483-495. doi: 10.1007/s00280-017-3509-0. Epub 2018 Jan 8. PubMed PMID: 29313067; PubMed Central PMCID: PMC5837827. 2: Fan F, Tonon G, Bashari MH, Vallet S, Antonini E, Goldschmidt H, Schulze-Bergkamen H, Opferman JT, Sattler M, Anderson KC, Jäger D, Podar K. Targeting Mcl-1 for multiple myeloma (MM) therapy: drug-induced generation of Mcl-1 fragment Mcl-1(128-350) triggers MM cell death via c-Jun upregulation. Cancer Lett. 2014 Feb 28;343(2):286-94. doi: 10.1016/j.canlet.2013.09.042. Epub 2013 Oct 8. PubMed PMID: 24120758. 3: Aguiló JI, Iturralde M, Monleón I, Iñarrea P, Pardo J, Martínez-Lorenzo MJ, Anel A, Alava MA. Cytotoxicity of quinone drugs on highly proliferative human leukemia T cells: reactive oxygen species generation and inactive shortened SOD1 isoform implications. Chem Biol Interact. 2012 Jun 25;198(1-3):18-28. doi: 10.1016/j.cbi.2012.05.001. Epub 2012 May 16. PubMed PMID: 22609468. 4: Chen YJ, Wang JJ, Chang LS. Naja nigricollis CMS-9 enhances the mitochondria-mediated death pathway in adaphostin-treated human leukaemia U937 cells. Clin Exp Pharmacol Physiol. 2011 Nov;38(11):755-63. doi: 10.1111/j.1440-1681.2011.05585.x. PubMed PMID: 21824174. |
Adaphostin - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.541 ml | 12.707 ml | 25.414 ml |
| 5 mM | 0.508 ml | 2.541 ml | 5.083 ml |
| 10 mM | 0.254 ml | 1.271 ml | 2.541 ml |
| 5 mM | 0.051 ml | 0.254 ml | 0.508 ml |
Last Update：2024-01-02 23:10:35
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