AdipoRon
AdipoRon
CAS: 924416-43-3
Molecular Formula: C27H28N2O3
AdipoRon - Names and Identifiers
AdipoRon - Physico-chemical Properties
| Molecular Formula | C27H28N2O3 |
| Molar Mass | 428.52 |
| Density | 1.21±0.1 g/cm3(Predicted) |
| Melting Point | 106-108°C |
| Boling Point | 645.3±55.0 °C(Predicted) |
| Solubility | DMSO: soluble10mg/mL, clear |
| Appearance | powder |
| Color | white to beige |
| pKa | 13.92±0.20(Predicted) |
| Storage Condition | room temp |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| In vitro study | AdipoRon increases AMPK activation, PGC-1α expression, and mitochondrial biosynthesis by binding to AdipoR1 and AdipoR2 in C2C12 myotubes. AdipoRon increases AMPK activation, PGC-1α expression, and mitochondrial biosynthesis by binding to AdipoR1 and AdipoR2 in C2C12 myotubes. |
| In vivo study | In skeletal muscle and liver of wild-type mice, adipron (50 μg/kg, I. v.) significantly induced phosphorylation of AMPK by AdipoR1 and adipor2. In WT mice, adipron (50 mg/kg, p.o.) insulin resistance, glucose intolerance, and dyslipidemia are improved by activating the AdipoR1-AMPK-PGC-1α pathway in skeletal muscle, or by activating the adipor2-ppar-α pathway in the liver. In addition, adipron can improve diabetes in db/db mice, a genetically obese rodent model, and prolong the shortened lifespan of db/db mice on a high-fat diet. In skeletal muscle and liver of wild-type mice, adipron (50 μg/kg, I. v.) significantly induced phosphorylation of AMPK via AdipoR1 and adipor2. In WT mice, adipron (50 mg/kg, p.o.) insulin resistance, glucose intolerance, and dyslipidemia are improved by activating the AdipoR1-AMPK-PGC-1α pathway in skeletal muscle, or by activating the adipor2-ppar-α pathway in the liver. In addition, adipron can improve diabetes in db/db mice, a genetically obese rodent model, and prolong the shortened lifespan of db/db mice on a high-fat diet. |
AdipoRon - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
AdipoRon - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.334 ml | 11.668 ml | 23.336 ml |
| 5 mM | 0.467 ml | 2.334 ml | 4.667 ml |
| 10 mM | 0.233 ml | 1.167 ml | 2.334 ml |
| 5 mM | 0.047 ml | 0.233 ml | 0.467 ml |
Last Update：2024-01-02 23:10:35
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Product Name: AdipoRon Visit Supplier Webpage Request for quotationCAS: 924416-43-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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Spot supply
Product Name: AdipoRon Visit Supplier Webpage Request for quotationCAS: 924416-43-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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