Adjudin
Adjudin
CAS: 252025-52-8
Molecular Formula: C15H12Cl2N4O
Adjudin - Names and Identifiers
Adjudin - Physico-chemical Properties
| Molecular Formula | C15H12Cl2N4O |
| Molar Mass | 335.19 |
| Density | 1.51±0.1 g/cm3(Predicted) |
| Solubility | DMSO: 34 mg/mL( < 1 mg/ml refers to the product slightly soluble or insoluble) |
| pKa | 11.88±0.30(Predicted) |
| Storage Condition | -20℃ |
| Use | Adjudin is a widely studied male contraceptive agent with superior mitochondrial inhibition. Adjudin is also an effective Cl-channel blocker. |
| In vitro study | Adjudin is a potent blocker of Cl - channels: disrupting Cl - ion transport function results in a decline in sperm capacitation and fertilizing ability in humans in vitro. Adjudin (ADD) is a mitochondria inhibitor. Adjudin is a molecule that mediates adherens junction disruption at the Sertoli-germ cell interface. To investigate the effect of Adjudin on cancer cells, more than ten different types of human or mice cancer cell lines are treated with increasing concentrations of Adjudin and the cell proliferation is measured by the modified MTT assay. Adjudin inhibits cell proliferation in a dose dependent manner in SGC-7901 (human gastric adenocarcinoma cell), MDA-MB-231 (human breast adenocarcinoma cell), Smmc-7721 (human hepatoma cell) and MIA Paca-2 (human pancreatic adenocarcinoma cell) cells. The IC 50 of Adjudin is determined to be 58.0 µM, 13.8 µM, 72.3 µM and 52.7 µM against SGC-7901, MDA-MB-231, Smmc-7721 and MIA Paca-2 cells, respectively, after treatment for 24 h. Similar results are obtained in other human and mice cancer cell lines. The IC 50 of Adjudin in A549 cells and PC3 cells is 63.1 µM and 93.0 µM, respectively. For WI-38 and BPH-1 cells, the IC 50 of Adjudin can be observed at more than 300 µM and 200 µM, respectively, which is about 5 times and 2 times more than that for the cancer cell lines A549 and PC3. |
| In vivo study | To determine whether Adjudin can inhibit lung and prostate cancer growth in vivo, the effect of Adjudin is tested in a subcutaneous model of lung and prostate cancer. Human lung carcinoma cells A549 and prostate carcinoma cells PC3 are injected into athymic nude mice subdermally at the lower back site respectively. Mice are then randomized into two treatment groups with similar mean tumor sizes: Adjudin and vehicle (control). Approximately 2 weeks after tumor inoculation Adjudin is injected intraperitoneally once every three days in lung carcinoma cells and every other day in prostate carcinoma cells at 100 mg/kg. Adjudin treatment can be well tolerated in rodent. And Adjudin-treated mice show significant tumor growth inhibition compared with the control group (P<0.0001 in the human lung carcinoma cells A549 and P=0.006 in the prostate carcinoma cells PC3). |
Adjudin - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.983 ml | 14.917 ml | 29.834 ml |
| 5 mM | 0.597 ml | 2.983 ml | 5.967 ml |
| 10 mM | 0.298 ml | 1.492 ml | 2.983 ml |
| 5 mM | 0.06 ml | 0.298 ml | 0.597 ml |
Last Update：2024-01-02 23:10:35
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Multiple Specifications
Product Name: Lonidamine Impurity 26 (Adjudin) Request for quotationCAS: 252025-52-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Adjudin Visit Supplier Webpage Request for quotationCAS: 252025-52-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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