Adriblastin

Adriblastin - Names and Identifiers

Name	Adriamycin
Synonyms	Rubex Adriacin ADRIAMYCIN Adriamycin DOXORUBICIN Adriblastin Doxorubicin Adriblastina Adriamycin PFS Adriamycin RDF 14-Hydroxydaunomycin Adriamycin Adriamycin Doxorubicin hydrohloride Rubex (hydrochloride salt) Adriacin (hydrochloride salt) adriblatina (hydrochloride salt) adiblastine (hydrochloride salt) Adriblastina (hydrochloride salt) adriablatina (hydrochloride salt) adriablastine (hydrochloride salt) Farmablastina (hydrochloride salt) Adriamycin RDF (hydrochloride salt) Adriamycin PFS (hydrochloride salt) Doxorubicin hydrochloride (hydrochloride salt) Hydroxydaunomycin hydrochloride (hydrochloride salt) Hydroxydaunorubicin hydrochloride (hydrochloride salt) 10-((3-amino-2,3,6-trideoxy-alpha-l-lyso-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione 10-((3-Amino-2,3,6-trideoxy-alpha-L-lyso-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione (1s,3s)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranoside (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside (8S-cis)-10-(3-Amino-2,3,6-Trideoxy-alpha-L-Lyxo-Hexopyranosyl)Oxy-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxy-5,12-Naphthacenedione 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, (8S,10S)-
CAS	23214-92-8
EINECS	245-495-6
InChI	InChI=1/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1

Adriblastin - Physico-chemical Properties

Molecular Formula	C27H29NO11
Molar Mass	543.53
Density	1.3783 (rough estimate)
Melting Point	205°C
Boling Point	617.77°C (rough estimate)
Flash Point	443.8°C
Water Solubility	Soluble
Vapor Presure	9.64E-28mmHg at 25°C
pKa	pKa 8.2 (Uncertain)
Storage Condition	Keep in dark place,Sealed in dry,2-8°C
Refractive Index	1.6400 (estimate)
Physical and Chemical Properties	The hydrochloride is an orange-red needle-like crystal. Melting Point 204-205 °c. Soluble in water, methanol. The aqueous solution was stable. Insoluble in benzene, ether, chloroform.
Use	Clinical for acute and chronic lymphocytic leukemia and solid tumor treatment. This product adverse reactions have myelosuppression myocardial toxicity.

Adriblastin - Risk and Safety

Toxicity

An anthracycline cytotoxic
antineoplastic that is produced by Streptomyces peucetius. The
LD50 in mice is 9.4 mg/kg, i.v. It is a carcinogen that inhibits
DNA and RNA synthesis by intercalating in double-stranded
DNA with the amino sugar in the minor groove and the 90-OH
group of the anthracycline ring hydrogen-bonded to the adjacent
guanine. It also alters membrane fluidity and ion transport, and
generates free radicals through a cytochrome P450-mediated
reductive process. In humans, it causes alopecia, stomatitis, nausea,
vomiting, diarrhea, cardiotoxicity (manifested by tachycardia),
and potentially fatal congestive heart failure.