Afloquanone
afloqualone
CAS: 56287-74-2
Molecular Formula: C16H14FN3O
Afloquanone - Names and Identifiers
| Name | afloqualone |
| Synonyms | H-495 HQ-495 HQ 495 Afloquanone afloqualone 6-aMino-2-fluoroMethyl-3-(o-tolyl)-4(3h)-quinaz... 6-Amino-2-fluoromethyl-3-(o-tolyl)-quinazolin-4(3H)-one 6-Amino-2-Fluoromethyl-3- (2-Tolyl)-3H-quinazolin-4-one 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)-4(3h)-quinazolinon 6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4(3H)-one 6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)-4(3H)-quinazolinone 4(3H)-quinazolinone, 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)- Afloqualone 6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)-quinazolin-4-one |
| CAS | 56287-74-2 |
| EINECS | 1592732-453-0 |
| InChI | InChI=1/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12(13)16(20)21/h2-8H,9,18H2,1H3 |
Afloquanone - Physico-chemical Properties
| Molecular Formula | C16H14FN3O |
| Molar Mass | 283.3 |
| Density | 1.2529 (estimate) |
| Melting Point | 195-196°C |
| Boling Point | 492.5±55.0 °C(Predicted) |
| Flash Point | 251.68°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 2.73±0.70(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.642 |
| Use | Skeletal muscle relaxants |
Afloquanone - Risk and Safety
| Toxicity | LD50 in mice (mg/kg): 315.1 i.p. (Tani) |
Afloquanone - Reference Information
| introduction | fluoroquinone was first listed in Japan in 1983. it was developed by Japan's Tanabe co., ltd. after more than 20 years of clinical application, it has proved to be a relaxant with good curative effect on facial and neck muscle spasm. As a muscle relaxant, fluoroquinone mainly acts on a wide range of upper spinal centers to relieve muscle hypertension. Its central muscle relaxation activity is about 22-29 times that of toluene propanol and 8-10 times that of chlormezadone. |
| Biological activity | Afloqualone (HQ-495) is a GABAergic reagent with agonist activity on the β subtype of GABAα receptor. Afloqualone has anti-vertigo and sedative effects, which are thought to be due to increased sensitivity of GABA receptors at the site of LVN neurons. |
| Target | Value |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | oral-rat LD50:249 mg/kg; Oral-mouse LD50: 397 mg/kg |
| flammability hazard characteristics | combustible; combustion releases toxic nitrogen oxides and fluoride smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
Last Update：2024-04-10 22:29:15
