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Aformoterol

Formoterol Fumarate

CAS: 43229-80-7

Molecular Formula: C42H52N4O12

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Aformoterol - Names and Identifiers

Name Formoterol Fumarate
Synonyms Atock
BD 40A
Foradil
YM-08316
Oxis pMDi
NSC 299587
CGP 25827A
Aformoterol
Perforomist
UNII-P3T5QA5J9N
Foradil Aerolizer
Foradil acrolizer
Foradil Certihaler
Formoterol Fumarate
FORMATEROL FUMATATE
Formoterol fumarate JP13
Formoterol fumarate 50 gram
formamide,n-(2-hydroxy-5-(1-hydroxy-2-((2-(4-methoxyphenyl)-1-methylethyl)amin
N-{2-hydroxy-5-[(1S)-1-hydroxy-2-{[(1S)-2-(4-methoxyphenyl)-1-methylethyl]amino}ethyl]phenyl}formamide
(R*,R*)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]PHENYL]FORMAMIDE FUMARATE
(R*,R*)-(+)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]-PHENYL]FORMAMIDE FUMARATE
N-[2-hydroxy-5-(1-hydroxy-2-{[2-(4-methoxyphenyl)-1-methylethyl]amino}ethyl)phenyl]formamide (2E)-but-2-enedioate (salt)
N-{2-hydroxy-5-[(1S)-1-hydroxy-2-{[(1S)-2-(4-methoxyphenyl)-1-methylethyl]amino}ethyl]phenyl}formamide (2E)-but-2-enedioate (salt)
N-{2-hydroxy-5-[(1R)-1-hydroxy-2-{[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino}ethyl]phenyl}formamide (2E)-but-2-enedioate (salt)
CAS 43229-80-7
EINECS 1308068-626-2
InChI InChI=1/C19H24N2O4.C4H4O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22;5-3(6)1-2-4(7)8/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+

Aformoterol - Physico-chemical Properties

Molecular FormulaC42H52N4O12
Molar Mass804.88
Melting Point138-140°C
Boling Point603.2°C at 760 mmHg
Flash Point318.6°C
Solubility Slightly soluble in water, soluble in methanol, slightly soluble in 2-propanol, practically insoluble in acetonitrile.
Vapor Presure2.12E-15mmHg at 25°C
Appearanceneat
ColorWhite to off-white
Maximum wavelength(λmax)['284nm(lit.)']
Merck14,4245
pKapKa1 7.9; pKa2 9.2(at 25℃)
Storage ConditionRoom temperature
StabilityStable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
UseUsed as a bronchodilator
In vitro studyFormoterol is a potent airway smooth muscle relaxant with high potency, high affinity and selectivity for β2 adrenoceptors. Formoterol appears to remain in airway smooth muscle for a period of time, and due to its relaxing effect on human airway smooth muscle able to withstand repeated washes, formoterol exhibits a "reconfirmed" relaxing effect after washout of the β-adrenoceptor antagonist. In experimental test systems, Formoterol was shown to be able to effectively inhibit these cells and processes. Formoterol, such as salbutamol and salmeterol, relaxes guinea pig trachea and human bronchus in ex vivo preparation and concentration-dependently inhibits antigen-induced release of inflammatory mediators from human lung slices.
In vivo studyDose-related inhibition of histamine-induced bronchoconstriction by Formoterol in conscious guinea pigs. In guinea pigs, Formoterol inhibited histamine-induced plasma protein exudation (PPE), with significant inhibition observed at doses of 10 mg/mL and 100 mg/ml. In guinea pig lung, Formoterol (100 mg/ml) inhibited PPE for 2-4 hours, between previously obtained salbutamol (1 hour) and salmeterol (> 6 hours). In guinea pig lung, Formoterol inhibits neutrophil aggregation (lipopolysaccharide-induced), but requires higher doses than inhibition of granulocyte-independent PPE (histamine-induced). Formoterol (100 mg/ml) inhibited PAF-induced eosinophil aggregation in guinea pig lung.

Aformoterol - Risk and Safety

UN IDs3249
RTECSLQ2988000
Hazard Class6.1(b)
Packing GroupII
ToxicityLD50 in male, female, rats, mice (mg/kg): 3130, 5580, 6700, 8310 orally; 98, 100, 72, 71 i.v.; 1000, 1100, 640, 670 s.c.; 170, 210, 240, 210 i.p. (Yoshida)
Aformoterol
Supplier List
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: Formoterol Fumarate Request for quotation
CAS: 43229-80-7
Tel: +86-17551318830
Email: r@reformchem.com­
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Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Formoterol Fumarate Request for quotation
CAS: 43229-80-7
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Formoterol Fumarate Request for quotation
CAS: 43229-80-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
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QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
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Product List: View Catalog
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: Formoterol Fumarate Request for quotation
CAS: 43229-80-7
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Formoterol Fumarate Request for quotation
CAS: 43229-80-7
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Formoterol Fumarate Request for quotation
CAS: 43229-80-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
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Aformoterol
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