Molecular Formula | C25H28O4 |
Molar Mass | 392.49 |
Melting Point | 121-123 ºC |
Boling Point | 600ºC at 760 mmHg |
Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
Appearance | Powder |
Storage Condition | 2-8℃ |
In vitro study | Glabrol (Compound 1) decreases cholesteryl ester formation with an IC 50 value of 26.0 μM in HepG2 cells. |
Plant Source: | licorice |
biological activity | Glabrol (Compound 1) is an isoprene flavonoid isolated from the ethanol extract of licorice root, it is a potent and non-competitive ACAT (acyl-CoA: Cholesterol acyltransferase) inhibitor with an IC50 value of 24.6 μm for rat liver microsomal ACAT. |