Aminocyclohexanol

Aminocyclohexanol - Names and Identifiers

Name	Aminocyclohexanol
Synonyms	aminocyclohexanol Aminocyclohexanol 2-Aminocyclohexanol 2-Aminocyclohenxanol 1-Amino-2-hydroxycyclohexane 2-Aminocyclohexanol (cis- and trans- mixture)
CAS	6850-38-0
InChI	InChI=1/C6H13NO/c7-5-3-1-2-4-6(5)8/h5-6,8H,1-4,7H2
InChIKey	PQMCFTMVQORYJC-UHFFFAOYSA-N

Aminocyclohexanol - Physico-chemical Properties

Molecular Formula	C6H13NO
Molar Mass	115.17
Density	1.037±0.06 g/cm3(Predicted)
Melting Point	65 °C
Boling Point	212 °C
Solubility	soluble in Methanol
Appearance	powder to crystal
Color	White to Light orange to Yellow
pKa	14.94±0.40(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
MDL	MFCD00191368

Aminocyclohexanol - Risk and Safety

Risk Codes	R34 - Causes burns R22 - Harmful if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs	3259
Hazard Note	Irritant
Hazard Class	8
Packing Group	III

Aminocyclohexanol - Reference Information

Overview

β-amino alcohol is an important basic chemical raw materials, in organic synthesis chemistry, pharmaceutical chemistry, synthetic chemistry of natural products and chemical production and other fields have important and extensive uses, but also widely used in medicine, pesticides, grinding aids, plasticizers, surfactants and other fields. Β-amino alcohols can be synthesized by reacting ethylene oxide, propylene oxide, and cyclohexene oxide with nucleophiles such as ammonia, amines, and alcohol amines. At present, β-amino alcohol is widely used in the synthesis of amino acids and chiral auxiliary asymmetric synthesis; Β-amino alcohol also plays a very important role in pharmaceutical chemistry, many clinically widely used drugs contain β-amino alcohol structural units. Therefore, the synthesis of β-amino alcohols has become a promising research topic in the field of organic synthesis. Reported in the literature with epoxy pentane and aniline as raw materials, dichloromethane as solvent, TaCl5 as the catalyst in the synthesis of β-amino alcohol route, in the presence of TaCl5-SiO2, Β-amino alcohol was synthesized by the stereoselective reaction of epoxy pentane and aniline with a yield of 83%. It is reported that the asymmetric hydrogenation of α-aminoketone catalyzed by the complex of ruthenium naphthalene diphenyl phosphonium can obtain β-aminoalcohol with high enantioselectivity. It is reported in the literature that the corresponding β-aminodiethylaluminum cyclohexyl ether is obtained by the treatment of cyclohexene oxide with diethylaluminum Amine, and then the corresponding 2-aminocyclohexanol is obtained by hydrolysis treatment.

Application

2-aminocyclohexanol is a kind of fine chemical product with wide application and great development value, its market demand will continue to expand. The product is widely used, can be used in medicine, pesticide, curing agent, plasticizer, diluent, surfactant and other fields.

Last Update：2024-04-09 20:49:11