biological activity | Andrographolide (Andro) andrographolide is a small antagonist that affects NF-κB activity by covalently modifying cysteine 62 of p50. Andrographolide (Andro) Andrographolide is a bicyclic diterpene lactone, mainly produced by Andrographis paniculate. Andrographolide (Andro) inhibits the activation of NF-κB in stimulated endothelial cells and reduces the expression of cell adhesion molecule E-selectin, E-selectin-mediated leukocyte adhesion was prevented but had no effect on IκBα degradation, p50 and p65 nuclear translocation. |