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Aprepitant(MK-0869)

Aprepitant

CAS: 170729-80-3

Molecular Formula: C23H21F7N4O3

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Aprepitant(MK-0869) - Names and Identifiers

Name Aprepitant
Synonyms Emend
CS-274
MK-0869
Aprepitant
Aprepitant(MK-0869)
Aprepitant (MK-0869, L-754030)
5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,
5-[2(R)-[1(R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-ylmethyl]-3,4-dihydro-2H-1,2,4-triazol-3-one
5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
5-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-1,2-dihydro-3H-1,2,4-triazol-3-one
5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one, Emend
CAS 170729-80-3
EINECS 677-636-6
InChI InChI=1/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1

Aprepitant(MK-0869) - Physico-chemical Properties

Molecular FormulaC23H21F7N4O3
Molar Mass534.43
Density1.51±0.1 g/cm3(Predicted)
Melting Point244-246°C
Specific Rotation(α)D25 +69° (c = 1.00 in methanol)
Solubility Soluble in DMSO (>25 mg/ml)
Appearancepowder
Colorwhite to beige
pKa8.06±0.20(Predicted)
Storage ConditionSealed in dry,2-8°C
StabilityStable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Refractive Index1.564

Aprepitant(MK-0869) - Risk and Safety

HS Code2934990002

Aprepitant(MK-0869) - Nature

Open Data Verified Data

white or slightly white crystals, insoluble in water, slightly soluble in acetonitrile, soluble in ethanol.

Last Update：2024-01-02 23:10:35

Aprepitant(MK-0869) - Preparation Method

Open Data Verified Data

2 (R) a [1_(R) a [3,5 A bis (tetrafluoromethyl) phenyl] ethoxy] A 3 (S) one (4 fluorophenyl) morpholine (R)-camphorsulfonate and potassium carbonate dissolved in dimethyl formamide, at 22 deg C to add 3 chloromethyl -1,2, A solution of 4-oxazolin-5-one in dimethylformamide was stirred, water was added, and the mixture was cooled with an ice bath. The crystals were collected by filtration, washed with water, and dried to obtain aprepitant.

Last Update：2022-01-01 09:23:29

Aprepitant(MK-0869) - Use

Open Data Verified Data

developed by MERCK & CO, Inc. and approved by FDA in March, 2003. Used to treat depression and chemotherapy-induced Vomit. Can prevent the first and after repeated chemotherapy caused by acute and delayed Nausea, Vomit.

Last Update：2022-01-01 09:23:30
Aprepitant(MK-0869)
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CAS: 170729-80-3
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CAS: 170729-80-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Aprepitant Visit Supplier Webpage Request for quotation
CAS: 170729-80-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Aprepitant Request for quotation
CAS: 170729-80-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Aprepitant Visit Supplier Webpage Request for quotation
CAS: 170729-80-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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Aprepitant(MK-0869)
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