Aristololactum
aristolactam I
CAS: 13395-02-3
Molecular Formula: C17H11NO4
Aristololactum - Names and Identifiers
| Name | aristolactam I |
| Synonyms | Ccris 1545 Brn 0307971 ARISTOLACTAM aristololactam Aristololactum aristolactam I Aristololactam I 8-methoxy[1,3]benzodioxolo[6,5,4-cd]benzo[f]indol-5(6H)-one 8-Methoxybenzo[f]-1,3-benzodioxolo[6,5,4-cd]indol-5(6H)-one Benzo(F)-1,3-benzodioxolo(6,5,4-cd)indol-5(6H)-one, 8-methoxy- 8-Methoxy-6-aminophenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid 5,6-lactam 3,4-Methylenedioxy-8-methoxy-10-aminophenanthrene-1-carboxylic acid 1,10-lactam |
| CAS | 13395-02-3 |
| InChI | InChI=1/C17H11NO4/c1-20-12-4-2-3-8-9(12)5-11-14-10(17(19)18-11)6-13-16(15(8)14)22-7-21-13/h2-6H,7H2,1H3,(H,18,19) |
Aristololactum - Physico-chemical Properties
| Molecular Formula | C17H11NO4 |
| Molar Mass | 293.27 |
| Density | 1.49 |
| Melting Point | 319 °C |
| Boling Point | 463.9±34.0 °C(Predicted) |
| Flash Point | 234.4°C |
| Solubility | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Vapor Presure | 8.75E-09mmHg at 25°C |
| Appearance | Yellow powder |
| Color | Light Yellow to Dark Yellow |
| pKa | 12.36±0.20(Predicted) |
| Storage Condition | Refrigerator |
| Refractive Index | 1.763 |
| MDL | MFCD00797313 |
| Physical and Chemical Properties | Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the ground can not be, Alternanthera philoxeroides. |
Aristololactum - Risk and Safety
| UN IDs | 2811 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
Aristololactum - Reference
| Reference Show more | 1. [IF=7.514] Huihuang Xiong et al."Thermosensitive and magnetic molecularly imprinted polymers for selective recognition and extraction of aristolochic acid I."Food Chem. 2022 Mar;372:131250 2. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 3. [IF=4.35] Xuan Yu et al."Study of the Contents of Analogues of Aristolochic Acid in Houttuynia cordata by Ultra-High Performance Liquid Chromatography Tandem Mass Spectrometry."Foods. 2022 Jan;11(3):302 |
Aristololactum - Reference Information
| biological activity | Aristololactam I (AL-I) is the main metabolite of aristolochic acid I (AA-I) and participates in the process of causing kidney injury. Aristololactam I (AL-I) directly damages renal proximal tubule cells, the cytotoxic effect of AL-I is higher than that of AA-I, and the cytotoxic effect of these molecules is mediated by caspase-3-dependent apoptosis. |
| use | aristolochia lactam has antibacterial and anti-inflammatory effects. used for content determination/identification/pharmacological experiment, etc. |
Last Update：2024-04-10 22:29:15
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