Atosibanum

Name	Atosiban
Synonyms	Atosiban RW-22164 rwj22164 RWJ-22164 Rwj 22164 ORF 22164 Atosibanum Tractocile atosiban price UNII-081D12SI0Z ATOSIBAN ACETATE Atosiban Impurtiy Atosibanum [INN-Latin] 1-deamino-2d-tyr-(oet)-4-thr-8-orn-oxytocin 1-Deamino-2D-tyr-(OEt)-4-thr-8-orn-oxytocin oxytocin,1-(3-mercaptopropanoicacid)-2-(o-ethyl-d-tyrosine)-4-l-threonine-8-l Oxytocin, 1-(3-mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithine- 1-(3-Mercaptopropionic acid)-2-(3-(p-ethoxyphenyl)-D-alanine)-4-L-threonine-8-L-ornithineoxytocin 1-({(4R,7S,13S,16R)-7-(2-amino-2-oxoethyl)-13-[(2S)-butan-2-yl]-16-(4-ethoxybenzyl)-10-[(1R)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-ornithylglycinamide
CAS	90779-69-4
EINECS	806-815-5
InChI	InChI=1/C43H67N11O12S2/c1-5-23(3)35-41(63)53-36(24(4)55)42(64)50-29(20-32(45)56)38(60)51-30(43(65)54-17-8-10-31(54)40(62)49-27(9-7-16-44)37(59)47-21-33(46)57)22-68-67-18-15-34(58)48-28(39(61)52-35)19-25-11-13-26(14-12-25)66-6-2/h11-14,23-24,27-31,35-36,55H,5-10,15-22,44H2,1-4H3,(H2,45,56)(H2,46,57)(H,47,59)(H,48,58)(H,49,62)(H,50,64)(H,51,60)(H,52,61)(H,53,63)/t23-,24+,27-,28+,29-,30-,31-,35-,36?/m0/s1

Molecular Formula	C43H67N11O12S2
Molar Mass	994.19
Density	1.254±0.06 g/cm3(Predicted)
Melting Point	>165oC (dec.)
Boling Point	1469.0±65.0 °C(Predicted)
Flash Point	842.2°C
Solubility	H2O: ≤100mg/mL
Vapor Presure	0mmHg at 25°C
Appearance	solid
Color	White to Off-White
pKa	12.81±0.70(Predicted)
Storage Condition	-20°C
Refractive Index	1.549
Physical and Chemical Properties	White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from synthesis.
In vitro study	Atosiban inhibits the oxytocin-mediated release of IP3 from the myometrial cell membrane. There is reduced release of intracellular, stored calcium from the sacroplasmic reticulum of myometrial cells, and reduced influx of Ca 2+ from the extracellular space through voltage gated channels. In addition, Atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua.
In vivo study	The posterior pituitary hormones, oxytocin and arginine vasopressin, differ in structure by only two amino acids, and Atosiban influences physiological effects of arginine vasopressin on the feto-maternal cardiovascular and renal systems. In late-gestation sheep, the administration of Atosiban for 1 hour fails to induce fetomaternal cardiovascular changes. Atosiban blocks the activation of oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice.

WGK Germany	3
RTECS	RS7590000

Last Update：2024-01-02 23:10:35

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Atosibanum

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