Aureociclin
chlortetracycline
CAS: 57-62-5
Molecular Formula: C22H23ClN2O8
Aureociclin - Names and Identifiers
Aureociclin - Physico-chemical Properties
| Molecular Formula | C22H23ClN2O8 |
| Molar Mass | 478.88 |
| Density | 1.2833 (rough estimate) |
| Melting Point | 168-169° |
| Boling Point | 821.1±65.0 °C(Predicted) |
| Specific Rotation(α) | D23 -275.0° (methanol) |
| Flash Point | 450.372°C |
| Water Solubility | 0.63g/L(25 ºC) |
| Vapor Presure | 0mmHg at 25°C |
| pKa | pKa 3.3 (Uncertain) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.6000 (estimate) |
| Physical and Chemical Properties | Golden crystalline powder, odorless, bitter. Melting point 168-169 °c (decomposition). Very slightly soluble in water, soluble in salt solution. Hydrochloride slightly soluble in methanol, water, ethanol, insoluble in acetone, ether, chloroform. Stable in air, dark color in light. |
Aureociclin - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 1 |
| RTECS | QI7750000 |
Aureociclin - Nature
Open Data Verified Data
crystalline powder, odorless, bitter. Melting point 168~169 °c (decomposition). Very slightly soluble in water, soluble in salt solution. Its hydrochloride is slightly soluble in methanol, water, ethanol, insoluble in acetone, ether, chloroform. Stable in air, dark color in light.
Last Update：2024-01-02 23:10:35
Aureociclin - Preparation Method
Open Data Verified Data
produced by the fermentation of Streptomyces aureus, fermentation by acidification, filtration to precipitate, dissolved in ethanol after acid analysis of crude product, and then dissolved, salt to its hydrochloride crystal.
Last Update：2022-01-01 10:10:52
Aureociclin - Use
Open Data Verified Data
chlortetracycline has inhibitory effect on Gram-positive and gram-negative bacteria, and can be used to treat typhoid fever, Pullorum and other diseases of livestock and poultry. Also as a growth-promoting agent for pig feed.
Last Update：2022-01-01 10:10:52
Aureociclin - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | chlortetracycline, also known as chlortetracycline, its hydrochloride is soluble in water, free base especially calcium salt is difficult to dissolve in water. Tetracycline antibiotics, is found in the culture of Actinomycetes antibacterial substances. Can Kill Rickettsia, Mycoplasma, chlamydia, atypical Mycobacterium and spirochete, suitable for sensitive Staphylococcus aureus, Streptococcus pyogenes, pneumonia Streptococcus and other Gram-positive bacteria and influenza Haemophilus and other sensitive Gram-negative bacteria caused by the treatment of superficial eye infections, but also can be used for other parts of the sensitive bacterial infection treatment. |
| chlortetracycline eye ointment Indications and Usage | conjunctivitis: Commonly known as pink eye disease, after using warm water to remove secretions, apply a little of this product, close eyes and rest for a moment, let the drug play its full role, 3 times a day, 1 time before going to bed at night. Stye: Commonly known as the needle, do not use the hand after the onset of extrusion, in order to avoid other complications. Before the formation of abscess, the effect of hot compress is very good. Hot compress with a hot towel for 20 minutes, then apply chlortetracycline eye ointment, close eyes and rest for a moment. 3 times a day. Erosion of mouth corner: when there is erosion of mouth corner, vitamin B2 can be taken. At the same time, cotton swabs are dipped in warm boiled water to clean the wound, dry and then apply this product to accelerate the healing. It usually improves in 3 days. Swelling: When the nasal mucosa has small swelling pain, you can use cotton wool dipped in chlortetracycline eye ointment applied to the nasal cavity, and slightly Press the nose, promote the absorption of swelling, accelerate healing, other parts of the swelling can also be used. Mouth and hand and foot crack: first wash dry with hot water, then apply a little of this product, hand and foot parts need to be fixed with adhesive, can accelerate wound healing. |
| mechanism of action | chlortetracycline is a fast-acting bacteriostatic agent. After entering the bacteria, it reversibly binds to the receptor on the 30S subunit of the bacterial ribosome, interfering with the binding of tRNA to the receptor on the mRNA-ribosome complex, preventing the extension of the peptide chain and inhibiting protein synthesis, thus, the growth and reproduction of the bacteria are rapidly inhibited. There are two main ways for chlortetracycline to enter the cell: one is passive diffusion through the hydrophilic group of the outer cell membrane; The other is active transport by the inner cell. |
| side effects | after oral administration, it is easy to cause gastrointestinal reactions such as Nausea, Vomit, Diarrhea, etc; in addition, broad-spectrum antibiotics such as chlortetracycline are used for a long time, because sensitive bacteria are eliminated, causing a large number of insensitive bacteria or fungi to multiply, which can lead to double infection of Staphylococcus, Candida and so on. |
| Use | chlortetracycline has inhibitory effect on Gram-positive bacteria and negative bacteria, and can treat typhoid fever, Pullorum and other diseases of livestock and poultry. Also as a growth-promoting agent. For pig feed. For broilers under 10 weeks of age, the dosage is 20-50g/t, and the withdrawal period is 7 days; For pigs under 2 months of age, the dosage is 25-75g/t, and the withdrawal period is 7 days. It is mainly used for the infection of gram-positive cocci and negative bacilli, and also used for the infection of Rickettsia such as typhus and scrub typhus. It is used as feed additive and animal medicine for most Gram-positive bacteria, gram-negative bacteria, Rickettsia, mycoplasma infection has curative effect belongs to antibiotics drugs Tylosin on swine dysentery, swine Pneumonia, swine atrophic rhinitis, chicken chronic respiratory disease, calf Mycoplasma caused by Pneumonia are effective. It can be used for pigs under 4 months of age, the dosage is 10-50g/t, the withdrawal period is 5 days; Pigs under 2 months of age, the dosage is 15-50g/t, the withdrawal period is 5 days; it can also be used for chicken feed, the dosage is 4-50g/t, the withdrawal period is 5 days, and the egg production period is disabled. |
| production method | is produced by fermentation of Streptomyces fradiae. This product is a broad-spectrum antibiotic extracted from the culture broth of golden streptomycin (strep tomyces aureus). produced by Streptomyces aureofacieus fermentation, the fermentation broth is acidified and filtered to obtain precipitate, dissolved in ethanol, and then acid-precipitated to obtain crude product, and then dissolved and formed salt to obtain hydrochloride crystal. |
Last Update：2024-04-09 21:54:55
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