Avandi
Rosiglitazone Maleate
CAS: 155141-29-0
Molecular Formula: C22H23N3O7S
Avandi - Names and Identifiers
| Name | Rosiglitazone Maleate |
| Synonyms | Avandi BRL-49653c RSIGLITAZONEMALEATE Rosigliazone maleate Rosiglitazone Maleate RosiglitazoneTartrate ROSIGLITAZONE MALEATE 5-{p-[2-(methyl-2-pyridylamino)ethoxy]benzyl}-2,4-thiazolidinedione maleate 5-{p-[2-(Methyl-2-pyridylamino)ethoxy]benzyl}-2,4-thiazolidinedione maleate 5-(4-(2-(Methyl(pyridin-2-yl)aMino)ethoxy)benzyl)thiazolidine-2,4-dione Maleate 5-((4-[2-(METHYL-2-PYRIDINYLAMINO)-ETHOXY]-PHENYL)-METHYLENE)-2,4-THIAZOLIDINEDIONE |
| CAS | 155141-29-0 |
| EINECS | 642-163-6 |
| InChI | InChI=1/C18H19N3O3S.C4H4O4/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15;5-3(6)1-2-4(7)8/h2-9,15H,10-12H2,1H3,(H,20,22,23);1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChIKey | HCDYSWMAMRPMST-NTCAYCPXSA-N |
Avandi - Physico-chemical Properties
| Molecular Formula | C22H23N3O7S |
| Molar Mass | 473.5 |
| Melting Point | 235-240°C |
| Boling Point | 585°C at 760 mmHg |
| Solubility | DMSO: ≥10 mg/mL |
| Appearance | grayish white solid |
| Color | White |
| pKa | 6.1; 6.8(at 25℃) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months |
| MDL | MFCD00871760 |
| Use | For the treatment of diabetes |
| In vitro study | Rosiglitazone is a thiazolidinedione insulin sensitizer used as an oral hypoglycemic agent. In rodent models of insulin resistance, Rosiglitazone has an insulin sensitizing activity that is 60 to 200 times greater than troglitazone,englitazone, or piogliazone. Rosiglitazone reduces hyperglycemia by increasing insulin sensitivity in adipose tissue, liver, and skeletal muscle. Thus, insulin sensitization may be due in part to Rosiglitazone affecting the expression of molecules involved in the insulin signaling cascade. In adipose tissue, Rosiglitazone-mediated PPARγ stimulation promotes adipocyte differentiation. Rosiglitazone may also promote the uptake of free fatty acids by adipose tissue, thus reducing systemic free fatty acid levels. Insulin sensitivity in liver and peripheral tissues may be indirectly modulated by Rosiglitazone-mediated changes in levels of fatty acids or adipocyte-derived factors such as adiponectin and TNFα. Rosiglitazone may also be involved in regulating the expression of adiponectin receptors in certain tissues, which may be related to some aspects of insulin sensitization. |
| In vivo study | Rosiglitazone (5 mg/kg, p.o.) decreases the serum glucose in diabetic rats. Rosiglitazone also decreases IL-6, TNF-α, and VCAM-1 levels in diabetic group. Rosiglitazone in combination with losartan increases glucose compared to diabetic and Los-treated groups. Rosiglitazone significantly ameliorates endothelial dysfunction indicated by a significantly lower contractile response to PE and Ang II and enhancement of ACh-provoked relaxation in aortas isolated from diabetic rats. |
Avandi - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/38 - Irritating to eyes and skin. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
Avandi - Reference
| Reference Show more | 1. Wang Xiaokang, Liu Qingxia, Ye Kai and Wei Songcheng, Ma Jinjin, Ye Chunling. Effects of 3-Hydroxypuerarin on 3T3-L1 Insulin Resistance in Adipocytes and Its Mechanism [J]. Chinese herbal medicine 2014 45(16):2352-2357. 2. Zhao Dan, Zhang Tingting, Peng Chunxiu, et al. Effects of tea brownin in Pu 'er tea on key enzymes of glycolipid metabolism and tissue sections of rats fed with high sugar diet [J]. Food Industry Technology, 2019(15):298-303. 3. Zhang Tingting, Wu Enkai, Peng Chunxiu, etc. Effects of Pu 'er Tea Tea Brown on Blood Glucose and Lipid Indexes in Rats with High Sugar Diet [J]. Food Science and Technology, 2018(7):53-59. 4. Hu Tianjiao, Jiang Zhen, Zhang Wenyou, et al. Effects of Radix Isatidis Aquatic Extract on Early Liver Injury in Diabetic Rats [J]. Chinese Modern Applied Pharmacy, 2017, 34(002):196-199. 5. Hu Tianjiao, Jiang Zhen, li Jiping, et al. Hypoglycemic Effect of Active Components of Radix Isatidis on Diabetic Rats [J]. Chinese Journal of New Drugs and Clinics, 2015(09):703-706. 6. Zhou Jie, Wu Yanmei, Liu Shanshan. Effects of Main Chemical Components of Xiaoke Pills on Glucose and Lipid Metabolism of Insulin Resistance Adipocytes [J]. Chinese Medicinal Materials, 2015(06):1270-1276. 7. Liu Qingxia, Ye Kaihe, wang Jingru, et al. Study on the mechanism of asiatic acid in improving insulin resistance of mouse adipocytes [J]. Chinese Journal of Pathophysiology, 2013. 8. Xiao Xinhua, Li Fen, Ran Li, Zhou Junlin, Li Han, Yang Jing, Liu Jianghua, Wen Gebo. Effects of rosiglitazone on the expression of zinc alpha2 glycoprotein and mitochondrial biosynthesis related factors in adipose tissue of db/db mice [J]. Chinese Journal of Modern Medicine, 2013,23(29):1-7. 9. Li Xun, Wang Dongsheng, Yao Ye. Effects of Gegen Jiaotai Pills on Serum Inflammatory Factors in Type 2 Diabetic Rats [J]. Journal of Hunan University of Traditional Chinese Medicine, 2018(6). |
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Product Name: Rosiglitazone Maleate Visit Supplier Webpage Request for quotationCAS: 155141-29-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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Product Name: Rosiglitazone maleate Visit Supplier Webpage Request for quotationCAS: 155141-29-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Rosiglitazone Maleate Visit Supplier Webpage Request for quotationCAS: 155141-29-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Rosiglitazone maleate Visit Supplier Webpage Request for quotationCAS: 155141-29-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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