BAVACHININ
BAVACHININ A
CAS: 19879-30-2
Molecular Formula: C21H22O4
BAVACHININ - Names and Identifiers
| Name | BAVACHININ A |
| Synonyms | bavachinin (s)-butenyl) BAVACHININ A BAVACHININ A(P) 7-o-methylbavachin 4'-hydroxy-7-methoxy-6-(3-methyl-2-butenyl)-flavanon 4'-hydroxy-7-methoxy-6-(3-methyl-2-butenyl)-flavanon 4'-HYDROXY-7-METHOXY-6-(3-METHYL-2-BUTENYL)-FLAVANONE 2,3-dihydro-2-(4-hydroxyphenyl)-7-methoxy-6-(3-methyl-2-4h-1-benzopyran-4-on 2-(4-hydroxyphenyl)-7-methoxy-6-(3-methylbut-2-en-1-yl)-2,3-dihydro-4H-chromen-4-one |
| CAS | 19879-30-2 |
| InChI | InChI=1/C21H22O4/c1-13(2)4-5-15-10-17-18(23)11-20(14-6-8-16(22)9-7-14)25-21(17)12-19(15)24-3/h4,6-10,12,20,22H,5,11H2,1-3H3 |
| InChIKey | VOCGSQHKPZSIKB-FQEVSTJZSA-N |
BAVACHININ - Physico-chemical Properties
| Molecular Formula | C21H22O4 |
| Molar Mass | 338.4 |
| Density | 1.182 |
| Melting Point | 139-145°C |
| Boling Point | 537.1±50.0 °C(Predicted) |
| Specific Rotation(α) | (CHCl3)-10.4 |
| Flash Point | 190.3°C |
| Solubility | Soluble in chloroform and methanol. |
| Vapor Presure | 3.76E-12mmHg at 25°C |
| Appearance | White powder or crystal |
| pKa | 9.66±0.30(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.589 |
| MDL | MFCD06858307 |
| Physical and Chemical Properties | Pale yellow crystal powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from psoralen. |
BAVACHININ - Risk and Safety
| Hazard Symbols | N - Dangerous for the environment |
| Risk Codes | 50 - Very Toxic to aquatic organisms |
| Safety Description | 61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
BAVACHININ - Reference
| Reference Show more | 1. Fan Lingqiu Xinsong Gaoyang et al. Simultaneous Determination of 10 Components in Psoralea corylifolia by HPLC [J]. Journal of Qiqihar Medical College 2018 39(16):73-76. 2. Chen, Xiumin, Yanfang Yang, and Yingtao Zhang. "Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in Vitro." Febs Letters 587.18 (2013): 2930-2935.https:// doi.org/10.1016/j.febslet. 2013.07. 3. Chen, Zhi-Jing, et al. "Dietary total prenylflavonoids from the fruits of Psoralea corylifolia L. prevents age-related cognitive deficits and down-regulates Alzheimer's markers in SAMP8 mice." Molecules 23.1 (2018): 196.https://doi.org/10.3390/molecules230 4. [IF=4.379] Li Kai et al."Quantitative analysis, pharmacokinetics and metabolomics study for the comprehensive characterization of the salt-processing mechanism of Psoraleae Fructus."Sci Rep-Uk. 2019 Jan;9(1):1-10 5. [IF=3.935] Tiehua Zhang et al."Quantitative structure-activity relationship for estrogenic flavonoids from Psoralea corylifolia."J Pharmaceut Biomed. 2018 Nov;161:129 6. [IF=3.267] Zhi-Jing Chen et al."Dietary Total Prenylflavonoids from the Fruits of Psoralea corylifolia L. Prevents Age-Related Cognitive Deficits and Down-Regulates Alzheimer's Markers in SAMP8 Mice."Molecules. 2018 Jan;23(1):196 7. [IF=2.675] Xiumin Chen et al."Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro."Febs Lett. 2013 Sep;587(18):2930-2935 |
BAVACHININ - Reference Information
| Overview | Psoralea corylifolia dihydro flavonoids methyl ether is a kind of isopentenyl flavonoids extracted from traditional Chinese medicine Psoralea corylifolia, has anti-inflammatory, anti-asthma, anti-oxidation and anti-tumor and other pharmacological effects, has a certain development prospect. |
| biological activity | pavachinin (7-o-methylpavachin) is a natural compound with anti-inflammatory and anti-angiogenic activity. |
| Target | TargetValue PPARγ (Cell-free assay) 223 nM(Ki) PPAR-β/δ (Cell-free assay) 5.275 μm (Ki) PPAR α (Cell-free assay) 7.881 μm (Ki) |
| Target | Value |
| PPARγ (Cell-free assay) | 223 nM(Ki) |
| PPAR-β/δ (Cell-free assay) | 5.275 μM(Ki) |
| PPARα (Cell-free assay) | 7.881 μM(Ki) |
| Chemical properties | light yellow crystal powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Psoralea corylifolia. |
| uses | Psoralea corylifolia dihydroxyflavone methyl ether has anti-angiogenic activity, inhibit tumor, inhibit tumor angiogenesis, anti-osteoporosis effect. for content determination/identification/pharmacological experiments, etc |
Last Update：2024-04-09 20:15:17
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