BAY61-3606
BAY 61-3606 (dihydrochloride)
CAS: 648903-57-5
Molecular Formula: C20H20Cl2N6O3
BAY61-3606 - Names and Identifiers
BAY61-3606 - Physico-chemical Properties
| Molecular Formula | C20H20Cl2N6O3 |
| Molar Mass | 463.3172 |
| Solubility | DMSO: ≥ 4.6 mg/mL |
| Appearance | Yellow solid. |
| Storage Condition | -20℃ |
| In vitro study | BAY 61-3606 is a highly specific inhibitor of Syk kinase. At a concentration of 4.7 μm, other tyrosine kinases such as Lyn, Fyn, Src, Itk, and Btk were not inhibited by BAY 61-3606. BAY 61-3606 inhibits B- cell receptor-mediated signaling pathways. Bay 61-3606 is also a sensitizer for TRAIL-induced apoptosis. Bay 61-3606 downregulated Mcl-1 in MCF-7 cells in a dose-and time-dependent manner. In MCF-7 and T47D cells, Bay 61-3606 reduced the phosphorylation of Syk. In breast cancer cells, Bay 61-3606 downregulates Mcl-1 independently of Syk. In MCF-7 cells. Bay 61-3606 promotes the degradation of ubiquitin/proteasome-dependent Mcl-1 protein and inhibits the phosphorylation of CDK9, the expression of RNA polymerase Ⅱ and Mcl-1. In Vitro, Bay 61-3606 inhibited CDK9 kinase activity with an IC50 value of 37 nM. |
| In vivo study | Bay 61-3606 was administered in combination with TRAIL, and the volume of transplanted tumors was significantly reduced after 20 days. Oral administration of BAY 61-3606(3 mg/kg) to rats significantly transplanted antigen-induced passive cutaneous anaphylaxis, bronchial stenosis, and bronchial edema. In addition, BAY 61-3606 attenuates antigen-induced airway inflammation in rats. |
BAY61-3606 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.158 ml | 10.792 ml | 21.583 ml |
| 5 mM | 0.432 ml | 2.158 ml | 4.317 ml |
| 10 mM | 0.216 ml | 1.079 ml | 2.158 ml |
| 5 mM | 0.043 ml | 0.216 ml | 0.432 ml |
Last Update：2024-01-02 23:10:35
BAY61-3606 - Reference Information
| biological activity | BAY-61-3606 is a potent and selective Syk kinase inhibitor, ki was 7.5 nM. BAY-61-3606 can induce cell cycle arrest and apoptosis. |
| Target | Value |
| Syk (Cell-free assay) | 7.5 nM(Ki) |
Last Update：2024-04-09 20:49:11
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Spot supply
Product Name: BAY 61-3606 (dihydrochloride) Visit Supplier Webpage Request for quotationCAS: 648903-57-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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