BAYER38819
Phosazetim
CAS: 4104-14-7
Molecular Formula: C14H13Cl2N2O2PS
BAYER38819 - Names and Identifiers
BAYER38819 - Physico-chemical Properties
| Molecular Formula | C14H13Cl2N2O2PS |
| Molar Mass | 375.21 |
| Density | 1.43±0.1 g/cm3(Predicted) |
| Melting Point | 104-106 °C |
| Boling Point | 441.9±55.0 °C(Predicted) |
| pKa | 2.67±0.50(Predicted) |
| Physical and Chemical Properties | The pure product is white crystal. M. p.107 ~ 109 ℃. Easily soluble in dichloromethane, slightly soluble in ethanol, chloroform, benzene and ether, insoluble in water. It is stable at room temperature and does not absorb moisture. Industrial products are light pink or light yellow powder with a purity of over 80%. |
BAYER38819 - Risk and Safety
| Risk Codes | R27/28 - R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | 2783 |
| Hazard Class | 6.1(a) |
| Packing Group | I |
| Toxicity | LD50 orl-rat: 3700 mg/kg FMCHA2 -,C117,83 |
BAYER38819 - References
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| toxicity | mouse acute oral LD50 was 15mg/kg, skin absorption acute LD50 was 60mg/kg. The oral LD50 of Gerbil was 12 mg/kg, and the LD50 of loess rat was 20 mg/kg. |
| Use | efficient, highly toxic, broad-spectrum organophosphorus rodenticide. It is used to kill citellus, sand rat, zokor, Brucella vole, plateau pika, Apodemus agricarus, vole and hamster. The killing effect on mice was unstable. The poisonous rat phosphorus is mixed into the powder grain, and the warning color is added, and then a small amount of water is added to process it into strips, blocks and sheets, which can be used after drying. It can also be directly mixed into the mouse food. The effective ingredient in the bait is 0.5~1%. After the rodents eat the lethal dose of the bait, the symptoms of poisoning usually appear in 4~6h, and most of them die within 24h. Avoid entrance and skin contact. This product is an acute rodenticide, which can inhibit cholinesterase and destroy the function of nervous system, leading to death. 3-4 hours after the bait poisoning symptoms, death within 24 hours. Can be used to kill rats and wild rats. |
| production method | p-chlorophenol, trichlorosulfon, acetamidine hydrochloride, triethylamine as raw materials, synthesis according to the following steps. The trichlorothiophos is dissolved in benzene, stirred, slowly dropped into the mixed solution of p-chlorophenol, benzene and triethylamine at room temperature, and the molar ratio of the raw materials is controlled to be 1:2:2:2: 1. After addition, incubation, reaction at 15-25 °c for 0.5h. Then, the mixture was washed with water, allowed to stand, and the aqueous solution of the lower triethylamine hydrochloride was separated. Take the upper acyl chloride-benzene solution, mix with acetamidine hydrochloride aqueous solution, stir, slowly drop sodium hydroxide solution at room temperature (molar ratio of p-chlorophenol: trichlorosulfon: triethylamine: acetamidine hydrochloride: sodium hydroxide = 1.0:0.5:1.0:0.6:1.2). After the dropwise addition, the reaction was carried out at outdoor temperature for 1H. Washing with water at 65 ° C. And filtration were carried out at the same time to obtain a white solid, which was a finished poison rat product after drying and was prepared into a poison bait with a content of 0.5. preparation of O,O-bis (p-chlorophenyl) thiophosphoryl chloride a certain amount of trichlorosulfon is reacted with metered amount of P-chlorophenol in the acid binding agent triethylamine to form the intermediate O,O-bis (p-chlorophenyl) thiophosphoryl chloride. Reaction with benzene as solvent, reaction temperature at room temperature, dropwise addition of p-chlorophenol, triethylamine and benzene mixture after completion of stirring reaction for 15~30min, adding water to precipitate triethylamine hydrochloride, water layer to recover triethylamine, the benzene layer is a phosphorus oxychloride benzene solution. Preparation of acetamidine hydrochloride in the presence of hydrochloric acid, acetonitrile and ethanol were first reacted, and then one molecule of ethanol was removed by ammonolysis to obtain acetamidine hydrochloride. Synthesis of poisonous rat phosphorus the metered amount of acetamidine hydrochloride and appropriate amount of water are added to the reaction kettle, and after stirring and dissolving, the phosphorus oxychloride benzene solution and the metered alkali are dropped simultaneously at room temperature for 10~15min, and the reaction is continued for 2H, after completion of the reaction, the material was vacuum filtered, the filter cake was washed with water and dried at 90 ° C. To form a raw powder, and the filtrate was distilled to recover benzene. The above production process can also be synthesized by phase transfer catalysis. It can avoid the anhydrous conditions in the preparation of the intermediate, does not need other separation steps, eliminates the expensive triethylamine as acid binding agent, and improves the yield by about 10%. It has obtained the Chinese patent (CN1051715B). The procedure was as follows: a 300L enamel kettle was charged with 100L of p-chlorophenol (containing 403g/L of p-chlorophenol), 15.4L of phosphorotrichloride and 400g of benzyltriethylammonium chloride (BTEAC) dissolved in 5L of water, stirred and cooled. 34L 30% NaOH was added dropwise, the reaction temperature was raised to 40~60 ℃, and the reaction was completed for 1~2H. When the material was lowered to 20 ℃, the material was centrifuged, washed with water and dried, the yield was 64% and the purity was 87.4%. |
| category | pesticide |
| toxicity grade | highly toxic |
| Acute toxicity | oral-rat LD50: 3.7 mg/kg; Oral-mouse LD50: 12 mg/kg |
| flammability hazard characteristics | thermal decomposition of toxic nitrogen oxides, sulfur oxides, sulfur oxides, chloride gases |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials |
| fire extinguishing agent | Sand, dry powder, foam |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:48:19
