BCNU, N,NBis(2-chloroethyl)-N-nitrosourea, NSC-409962, Becenun, Bicnu,
carmustine
CAS: 154-93-8
Molecular Formula: C5H9Cl2N3O2
BCNU, N,NBis(2-chloroethyl)-N-nitrosourea, NSC-409962, Becenun, Bicnu, - Names and Identifiers
| Name | carmustine |
| Synonyms | BCUN BCNU BICNU BECENUN CARMUSTIN Carmustin carmustine CARMUSTINE bis(2-chloroethyl)nitrosourea 1,3-bis(2-chloroethyl)-1-nitroso-urea BCNU, N,NBis(2-chloroethyl)-N-nitrosourea, NSC-409962, Becenun, Bicnu, |
| CAS | 154-93-8 |
| EINECS | 205-838-2 |
| InChI | InChI=1/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11) |
| InChIKey | DLGOEMSEDOSKAD-UHFFFAOYSA-N |
BCNU, N,NBis(2-chloroethyl)-N-nitrosourea, NSC-409962, Becenun, Bicnu, - Physico-chemical Properties
| Molecular Formula | C5H9Cl2N3O2 |
| Molar Mass | 214.05 |
| Density | 1.6948 (rough estimate) |
| Melting Point | 30 °C (lit.) |
| Appearance | (Oily liquid to amorphous solid) |
| Color | Light-yellow powder |
| Merck | 14,1845 |
| pKa | 10.19±0.46(Predicted) |
| Storage Condition | -20°C |
| Refractive Index | 1.6100 (estimate) |
| Physical and Chemical Properties | Melting Point: 30 water-soluble:<0.1g/100 mL at 18 C |
BCNU, N,NBis(2-chloroethyl)-N-nitrosourea, NSC-409962, Becenun, Bicnu, - Risk and Safety
| Hazard Symbols | T+ - Very toxic |
| Risk Codes | R45 - May cause cancer R46 - May cause heritable genetic damage R60 - May impair fertility R61 - May cause harm to the unborn child R28 - Very Toxic if swallowed |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 3249 |
| WGK Germany | 3 |
| RTECS | YS2625000 |
| HS Code | 29241990 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
| Toxicity | LD50 in mice (mg/kg): 19-25 orally, 26 i.p., 24 s.c.; in rats (mg/kg): 30-34 orally (Thompson, Larson) |
BCNU, N,NBis(2-chloroethyl)-N-nitrosourea, NSC-409962, Becenun, Bicnu, - Standard
Authoritative Data Verified Data
This product is 1, 3-bis (2-chloroethyl)-l-nitrosourea. The content of C5H9C12N302 shall be between 96.0% and 101.0% based on the dry product.
Last Update：2024-01-02 23:10:35
BCNU, N,NBis(2-chloroethyl)-N-nitrosourea, NSC-409962, Becenun, Bicnu, - Trait
Authoritative Data Verified Data
- This product is colorless to yellowish or yellowish green crystalline or crystalline powder; Odorless.
- This product is dissolved in methanol or ethanol, insoluble in water.
melting point
The melting point of this product (General rule 0612) is 30~32°C, and it is decomposed at the same time during melting.
Last Update：2022-01-01 11:37:12
BCNU, N,NBis(2-chloroethyl)-N-nitrosourea, NSC-409962, Becenun, Bicnu, - Differential diagnosis
Authoritative Data Verified Data
- take about 50mg of this product, add 5ml of 0.5mol/L sodium hydroxide solution, put it on a water bath and heat it for 5 minutes, and continuously shake it to dissolve it. Add 1 drop of phenolphthalein indicator solution, add Dropwise to colorless with nitric acid solution (1-2), add 0.lmol/L silver nitrate solution lml, should produce white precipitate.
- take this product and add water to make a solution containing 10ug per lml. Take 2ml of this solution and add lml of sulfonamide solution (take 50mg of sulfonamide and dissolve 10ml of 2mol/L hydrochloric acid solution), after 45 minutes on a water bath at 50°C, cool in an ice bath, add 0.2ml of 1% AK methylnaphthyl) diaminoethylene hydrochloride solution, which should be red after 10 minutes.
- the solution under the content measurement was measured by ultraviolet-visible spectrophotometry (General 0401), and the maximum absorption was found at a wavelength of Nm.
Last Update：2022-01-01 11:37:13
BCNU, N,NBis(2-chloroethyl)-N-nitrosourea, NSC-409962, Becenun, Bicnu, - Exam
Authoritative Data Verified Data
loss on drying
take this product, put it in a phosphorus pentoxide dryer, and dry it under reduced pressure to constant weight. The weight loss shall not exceed 0.5% (General rule 0831).
Last Update：2022-01-01 11:37:13
BCNU, N,NBis(2-chloroethyl)-N-nitrosourea, NSC-409962, Becenun, Bicnu, - Content determination
Authoritative Data Verified Data
accurately weigh the appropriate amount of this product, add anhydrous ethanol to dissolve and quantitatively dilute to make a solution containing about 20ug per lml, according to UV-visible spectrophotometry (General 0401), the absorbance was measured at a wavelength of 230mn, and calculated as the absorption coefficient of C5H9Cl2N302 is 270 (the measurement should be performed at 20 ° C. Or lower in 30 minutes).
Last Update：2022-01-01 11:37:14
BCNU, N,NBis(2-chloroethyl)-N-nitrosourea, NSC-409962, Becenun, Bicnu, - Category
Authoritative Data Verified Data
antineoplastic agents.
Last Update：2022-01-01 11:37:14
BCNU, N,NBis(2-chloroethyl)-N-nitrosourea, NSC-409962, Becenun, Bicnu, - Storage
Authoritative Data Verified Data
light-shielding, sealed, stored in cold place.
Last Update：2022-01-01 11:37:14
BCNU, N,NBis(2-chloroethyl)-N-nitrosourea, NSC-409962, Becenun, Bicnu, - Carmustine injection
Authoritative Data Verified Data
This product is a polyethylene glycol sterilization solution of carmustine. The inclusion of carmustine (C5H9C12N302) shall be between 90.0% and 110.0% of the indicated amount.
trait
This product is a light yellow clear liquid.
identification
take this product, according to carmustine under the identification test, showed the same results.
examination
- loading capacity take 5 pieces of this product, according to the minimum amount of inspection method (General rule 0942 heavy children Law) according to law inspection, each load should be not less than 2g.
- bacterial endotoxin this product, according to the law inspection (General 1143), the amount of endotoxin per 1 mg carmustine should be less than 0.70EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
an appropriate amount of carmustine was accurately weighed, dissolved by anhydrous fermentation and quantitatively diluted to prepare a solution containing about 20ug of carmustine per 1 ml, which was obtained by measuring according to the method under the item of carmustine content measurement.
category
Same as carmustine.
specification
2g:125mg
storage
light shielding, closed, stored in cold place.
Last Update：2022-01-01 11:37:15
Supplier List
Spot supply
Product Name: Carmustine Visit Supplier Webpage Request for quotationCAS: 154-93-8
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Carmustin Visit Supplier Webpage Request for quotationCAS: 154-93-8
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Multiple SpecificationsSpot supply
Product Name: Carmustine Visit Supplier Webpage Request for quotationCAS: 154-93-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Carmustine Visit Supplier Webpage Request for quotationCAS: 154-93-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: carmustine Request for quotation
CAS: 154-93-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 154-93-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: CARMUSTINE Visit Supplier Webpage Request for quotationCAS: 154-93-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Carmustine Visit Supplier Webpage Request for quotationCAS: 154-93-8
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Carmustin Visit Supplier Webpage Request for quotationCAS: 154-93-8
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Multiple SpecificationsSpot supply
Product Name: Carmustine Visit Supplier Webpage Request for quotationCAS: 154-93-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Carmustine Visit Supplier Webpage Request for quotationCAS: 154-93-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: carmustine Request for quotation
CAS: 154-93-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 154-93-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: CARMUSTINE Visit Supplier Webpage Request for quotationCAS: 154-93-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History
BCNU, N,NBis(2-chloroethyl)-N-nitrosourea, NSC-409962, Becenun, Bicnu,
2-环戊酮
戊酸戊酯(异戊酸异戊酯)
SULFATE STANDARD SOLUTION
正癸基三甲氧基硅烷
阿拉莫林杂质
莫西沙星异构体杂质
2-环戊酮
戊酸戊酯(异戊酸异戊酯)
SULFATE STANDARD SOLUTION
正癸基三甲氧基硅烷
阿拉莫林杂质
莫西沙星异构体杂质