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CARMUSTINE

carmustine

CAS: 154-93-8

Molecular Formula: C5H9Cl2N3O2

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CARMUSTINE - Names and Identifiers

Name carmustine
Synonyms BCUN
BCNU
BICNU
BECENUN
CARMUSTIN
Carmustin
carmustine
CARMUSTINE
bis(2-chloroethyl)nitrosourea
1,3-bis(2-chloroethyl)-1-nitroso-urea
BCNU, N,NBis(2-chloroethyl)-N-nitrosourea, NSC-409962, Becenun, Bicnu,
CAS 154-93-8
EINECS 205-838-2
InChI InChI=1/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
InChIKey DLGOEMSEDOSKAD-UHFFFAOYSA-N

CARMUSTINE - Physico-chemical Properties

Molecular FormulaC5H9Cl2N3O2
Molar Mass214.05
Density1.6948 (rough estimate)
Melting Point30 °C (lit.)
Appearance(Oily liquid to amorphous solid)
ColorLight-yellow powder
Merck14,1845
pKa10.19±0.46(Predicted)
Storage Condition-20°C
Refractive Index1.6100 (estimate)
Physical and Chemical Properties

Melting Point: 30

water-soluble:<0.1g/100 mL at 18 C

CARMUSTINE - Risk and Safety

Hazard SymbolsT+ - Very toxic
Very toxic
Risk CodesR45 - May cause cancer
R46 - May cause heritable genetic damage
R60 - May impair fertility
R61 - May cause harm to the unborn child
R28 - Very Toxic if swallowed
Safety DescriptionS53 - Avoid exposure - obtain special instructions before use.
S22 - Do not breathe dust.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs3249
WGK Germany3
RTECSYS2625000
HS Code29241990
Hazard Class6.1(a)
Packing GroupII
ToxicityLD50 in mice (mg/kg): 19-25 orally, 26 i.p., 24 s.c.; in rats (mg/kg): 30-34 orally (Thompson, Larson)

CARMUSTINE - Standard

Authoritative Data Verified Data

This product is 1, 3-bis (2-chloroethyl)-l-nitrosourea. The content of C5H9C12N302 shall be between 96.0% and 101.0% based on the dry product.

Last Update：2024-01-02 23:10:35

CARMUSTINE - Trait

Authoritative Data Verified Data
  • This product is colorless to yellowish or yellowish green crystalline or crystalline powder; Odorless.
  • This product is dissolved in methanol or ethanol, insoluble in water.

melting point

The melting point of this product (General rule 0612) is 30~32°C, and it is decomposed at the same time during melting.

Last Update：2022-01-01 11:37:12

CARMUSTINE - Differential diagnosis

Authoritative Data Verified Data
  1. take about 50mg of this product, add 5ml of 0.5mol/L sodium hydroxide solution, put it on a water bath and heat it for 5 minutes, and continuously shake it to dissolve it. Add 1 drop of phenolphthalein indicator solution, add Dropwise to colorless with nitric acid solution (1-2), add 0.lmol/L silver nitrate solution lml, should produce white precipitate.
  2. take this product and add water to make a solution containing 10ug per lml. Take 2ml of this solution and add lml of sulfonamide solution (take 50mg of sulfonamide and dissolve 10ml of 2mol/L hydrochloric acid solution), after 45 minutes on a water bath at 50°C, cool in an ice bath, add 0.2ml of 1% AK methylnaphthyl) diaminoethylene hydrochloride solution, which should be red after 10 minutes.
  3. the solution under the content measurement was measured by ultraviolet-visible spectrophotometry (General 0401), and the maximum absorption was found at a wavelength of Nm.
Last Update：2022-01-01 11:37:13

CARMUSTINE - Exam

Authoritative Data Verified Data

loss on drying

take this product, put it in a phosphorus pentoxide dryer, and dry it under reduced pressure to constant weight. The weight loss shall not exceed 0.5% (General rule 0831).

Last Update：2022-01-01 11:37:13

CARMUSTINE - Content determination

Authoritative Data Verified Data

accurately weigh the appropriate amount of this product, add anhydrous ethanol to dissolve and quantitatively dilute to make a solution containing about 20ug per lml, according to UV-visible spectrophotometry (General 0401), the absorbance was measured at a wavelength of 230mn, and calculated as the absorption coefficient of C5H9Cl2N302 is 270 (the measurement should be performed at 20 ° C. Or lower in 30 minutes).

Last Update：2022-01-01 11:37:14

CARMUSTINE - Category

Authoritative Data Verified Data

antineoplastic agents.

Last Update：2022-01-01 11:37:14

CARMUSTINE - Storage

Authoritative Data Verified Data

light-shielding, sealed, stored in cold place.

Last Update：2022-01-01 11:37:14

CARMUSTINE - Carmustine injection

Authoritative Data Verified Data

This product is a polyethylene glycol sterilization solution of carmustine. The inclusion of carmustine (C5H9C12N302) shall be between 90.0% and 110.0% of the indicated amount.

trait

This product is a light yellow clear liquid.

identification

take this product, according to carmustine under the identification test, showed the same results.

examination

  • loading capacity take 5 pieces of this product, according to the minimum amount of inspection method (General rule 0942 heavy children Law) according to law inspection, each load should be not less than 2g.
  • bacterial endotoxin this product, according to the law inspection (General 1143), the amount of endotoxin per 1 mg carmustine should be less than 0.70EU.
  • others should comply with the relevant provisions under injection (General 0102).

Content determination

an appropriate amount of carmustine was accurately weighed, dissolved by anhydrous fermentation and quantitatively diluted to prepare a solution containing about 20ug of carmustine per 1 ml, which was obtained by measuring according to the method under the item of carmustine content measurement.

category

Same as carmustine.

specification

2g:125mg

storage

light shielding, closed, stored in cold place.

Last Update：2022-01-01 11:37:15
CARMUSTINE
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Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: carmustine Request for quotation
CAS: 154-93-8
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Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: carmustine Request for quotation
CAS: 154-93-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
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CARMUSTINE
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