BETA-LAPACHONE
β-Lapachone
CAS: 4707-32-8
Molecular Formula: C15H14O3
BETA-LAPACHONE - Names and Identifiers
BETA-LAPACHONE - Physico-chemical Properties
| Molecular Formula | C15H14O3 |
| Molar Mass | 242.27 |
| Density | 1.25±0.1 g/cm3(Predicted) |
| Melting Point | >110°C (dec.) |
| Boling Point | 381.4±42.0 °C(Predicted) |
| Solubility | Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml) |
| Appearance | Orange to brown solid. |
| Color | Orange |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.、 |
| In vitro study | Beta-Lapachone inhibited DNA relaxation induced by DNA topoisomerase I in a dose-dependent manner. Beta-lapacone (100 nM or higher) treatment inhibited Topo I DNA stretching activity by more than 95% compared with the control group. Beta-Lapachone(1-5 μm) acts on HL-60 and three prostate cancer (DU-145, PC-3, and LNCaP) cells to arrest the cell cycle at the G0/G1 phase, and induce apoptosis by locking Topo I on DNA and preventing replication fork movement. Beta-Lapachone acts on mouse 3T3 fibroblasts and human endothelial cells EAhy926 cells in vitro to promote cell migration through different MAPK signaling pathways, thereby accelerating wound healing. In addition, Beta-Lapachone non-competitive inhibition of purified recombinant IDO1 activity, IC50 was 0.44 μm, Beta-Lapachone also inhibited intracellular IDO1 inhibitory activity, IC50 was 1.0 μm, it is partly dependent on biotransformation by NQO1. Beta-Lapachone induces programmed necrosis of NQO1 + cancer cells through nqo1-dependent formation of reactive oxygen species (ROS) and PARP1 overactivation. |
| In vivo study | Beta-Lapachone A mouse model of human ovarian cancer xenografts at a dose of 50 mg/kg can effectively inhibit tumor growth in vivo, and Beta-Lapachone combined with Taxol can Synergistically Induce cell apoptosis. Beta-Lapachone treatment of normal and diabetic (db/db) mice accelerated the healing process compared to the blank control group. |
BETA-LAPACHONE - Risk and Safety
| WGK Germany | 3 |
| RTECS | QL6127400 |
BETA-LAPACHONE - Reference
| Reference Show more | 1. [IF=7.46] Yongjun Zheng et al."Electrochemiluminescent detection of hNQO1 and associated drug screening enabled by futile redox cycle reaction."Sensor Actuat B-Chem. 2020 Oct;321:128557 |
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Spot supply
Product Name: β-Lapachone Visit Supplier Webpage Request for quotationCAS: 4707-32-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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