Name | 4,4'-dianilino-1,1'-binaphthyl-5,5'-di-sulfonic A |
Synonyms | BIS-ANS BIS-ANS DIPOTASSIUM SALT 8-Anilino-1-naphthalenesulfonic Acid Di 4,4'-dianilino-1,1'-binaphthyl-5,5'-di-sulfonic A 4,4'-Bis(1-anilinonaphthalene-8-sulfonic Acid) DipotassiuM Salt BIS-(5,5')-8-ANILINO-1-NAPHTHALENE SULFONIC ACID DIPOTASSIUM SALT 4,4'-DIANILINO-1,1'-BINAPHTHYL-5,5'-DISULFONIC ACID, POTASSIUM SALT 4,4'-DIANILINO-1,1'-BINAPHTHYL-5,5'-DISULFONIC ACID DIPOTASSIUM SALT 4,4'-Bis(phenylaMino)-[1,1'-binaphthalene]-5,5'-disulfonic Acid PotassiuM Salt |
CAS | 65664-81-5 |
InChI | InChI=1/C32H24N2O6S2.2K/c35-41(36,37)29-15-7-13-25-23(17-19-27(31(25)29)33-21-9-3-1-4-10-21)24-18-20-28(34-22-11-5-2-6-12-22)32-26(24)14-8-16-30(32)42(38,39)40;;/h1-20,33-34H,(H,35,36,37)(H,38,39,40);;/q;2*+1/p-2 |
Molecular Formula | C32H22K2N2O6S2 |
Molar Mass | 672.85 |
Color | light yellow |
BRN | 5714637 |
In vitro study | Bis-ANS is a fluorescent molecule that has been used to probe exposed hydrophobic patches in proteins and to monitor the formation of protein aggregates. Bis-ANS is a bivalent naphthalene sulfonate with aniline moieties. Bis-ANS modulates the liquid-liquid phase separation of TDP-43 low complexity domain (LCD). |
Hazard Symbols | Xn - Harmful |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
FLUKA BRAND F CODES | 3-10 |
biological activity | Bis-ANS dipitasite is a protein fluorescent probe that binds Bis-ANS to tubulin with a Kd of 2 μm. Bis-ANS dipotassium is an effective biphasic regulator of protein liquid-liquid phase separations (LLPS). Low concentration of Bis-ANS dipotassium promoted LLPS, and high concentration inhibited LLPS. |