BKT140

Name	BKT140
Synonyms	BKT140 BL-8040 TF14016 Motixafortide MOTIXAFORTIDE BKT140 (BL-8040) 4F-Benzoyl-TN14003 BKT140 4-fluorobenzoyl BKT140CXCR4 antagonist
CAS	664334-36-5

Molecular Formula	C97H144FN33O19S2
Molar Mass	2159.52
Density	1.52±0.1 g/cm3(Predicted)
Solubility	DMSO: ≥ 36 mg/mL
Storage Condition	-20℃
In vitro study	Motixafortide (BKT140) displays selective toxicity toward AmL and MM cells. Treatment with Motixafortide (BKT140) can overcome IL-6 dependent proliferation and survival of ARH77 MM cells. Motixafortide (BKT140) specifically triggers CXCR4-dependent cell death in leukemia and MM cells. Motixafortide (BKT140) stimulates apoptotic cell death in leukemia and MM cells.
In vivo study	Subcutaneous injections of Motixafortide (BKT140) significantly reduces, in a dose-dependent manner, the growth of human acute myeloid leukemia and multiple myeloma xenografts. Tumors from animals treated with Motixafortide (BKT140) are smaller in size and weights, had larger necrotic areas and high apoptotic scores.

Last Update：2024-01-02 23:10:35

biological activity	motif (BL-8040, BKT140, TF 14016, 4-fluorobenzol, 4f-benzo yl- tn14003, T140) is an antagonist of CXCR4 with an IC50 value of approximately 1 nM. BL-8040 apoptosis of AML embryos was induced by down-regulation of ERK, miR-15a, BCL-2 and MCL-1 by altered expression of cyclin-D1/16-1.
Target	Value
ERK ()
Bcl-2 ()
MCL-1 ()
cyclin-D1 ()
CXCR4 (Cell-free assay)	1 nM

Last Update：2024-04-09 21:11:58

Product Name: BKT140 Visit Supplier Webpage Request for quotation
CAS: 664334-36-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: BKT140 Visit Supplier Webpage Request for quotation
CAS: 664334-36-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

BKT140

BKT140 Request for Quotation