Molecular Formula | C24H24Cl2N4O4 |
Molar Mass | 503.38 |
Density | 1.39±0.1 g/cm3(Predicted) |
Solubility | DMSO: ≥ 25 mg/mL |
pKa | 13.77±0.40(Predicted) |
Storage Condition | -20℃ |
In vitro study | BLU-554 interacts with FGFR4 and has high potency and selectivity for inhibition of fgfr4. |
In vivo study | BLU-554 was well tolerated in tumor models. Induction of tumor regression in a liver cancer model. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.987 ml | 9.933 ml | 19.866 ml |
5 mM | 0.397 ml | 1.987 ml | 3.973 ml |
10 mM | 0.199 ml | 0.993 ml | 1.987 ml |
5 mM | 0.04 ml | 0.199 ml | 0.397 ml |