BLZ-945
4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide
CAS: 953769-46-5
Molecular Formula: C20H22N4O3S
BLZ-945 - Names and Identifiers
BLZ-945 - Physico-chemical Properties
| Molecular Formula | C20H22N4O3S |
| Molar Mass | 398.48 |
| Density | 1.377±0.06 g/cm3(Predicted) |
| Solubility | DMSO: ≥ 30 mg/mL |
| pKa | 13.92±0.46(Predicted) |
| Storage Condition | -20℃ |
| Physical and Chemical Properties | Bioactive BLZ945 is an orally active, potent selective CSF-1R inhibitor with an IC50 of 1 nM, which is more than 1000 times more selective than its nearest receptor tyrosine kinase homolog. |
| In vitro study | In bone marrow-derived macrophages (BMDMs), BLZ945 specific indications CSF-1-dependent propagation with EC50 of 67nM, and causes CSF-1R propagation. BLZ945 blocks. in bone marrow-derived macrophages (BMDMs), BLZ945 specifically inhibited CSF-1-dependent proliferation with an EC50 of 67nm and reduced phosphorylation by CSF-1R. BLZ945 blocks the interaction of macrophages and glioma cells in survival, proliferation and/or polarization, thereby inhibiting their pro-tumorigenesis. |
| In vivo study | In glioma-bearing mice, BLZ945 blocks tumor progression and significantly improves survival via CSF-1R inhibition. BLZ945 also inhibits orthotopic tumor growth of patient-derived proneural tumor spheres and cell lines in vivo. BLZ945 (200 mg/kg, p.o.) decreases the growth of malignant cells in both mouse mammary tumor virus-driven polyomavirus middle T antigen (MMTV-PyMT) model of mammary carcinoma and kernel 14-expressing human papillomavirus type 16 (K14-HPV-16) transgenic model of cerical carcinoma. in glioma-bearing mice, BLZ945 blocked tumor progression and significantly improved survival by CSF-1R inhibition. BLZ945 also inhibits orthotopic tumor growth in vivo from patient-derived primitive neurospheres and cell lines. Virus intermediate T antigen (Virus) model of mammary tumor MMTV-PyMT-driven oncogenic breast cancer in mice, and keratin 14 expression in oncogenic human papillomavirus type 16 Virus (K14-HPV-16) in transgenic models, BLZ945 (200 mg/kg, p.o.) reduces the growth of malignant cells. |
BLZ-945 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.51 ml | 12.548 ml | 25.095 ml |
| 5 mM | 0.502 ml | 2.51 ml | 5.019 ml |
| 10 mM | 0.251 ml | 1.255 ml | 2.51 ml |
| 5 mM | 0.05 ml | 0.251 ml | 0.502 ml |
Last Update：2024-01-02 23:10:35
BLZ-945 - Uses and synthesis methods
Target
Target Value
CSF-1R
(Cell-free assay) 1 nM
in vitro studies
In bone marrow-derived macrophages (BMDMs), BLZ945 specifically inhibits CSF-1-dependent proliferation, EC50 is 67nM, and reduces CSF-1R phosphorylation. BLZ945 blocks the interaction of macrophages and glioma cells in survival, proliferation, and/or polarization, thereby inhibiting their pro-tumorigenesis.
In vivo studies
in glioma-loaded mice, BLZ945 blocked tumor development and significantly improved survival rate through CSF-1R inhibition. BLZ945 can also inhibit the growth of ortho-tumor cells and cell lines derived from patients. BLZ945 (200 mg/kg, p.o.) reduced the growth of malignant cells in mouse mammary tumor virus-driven polyomavirus intermediate T antigen (MMTV-PyMT) model and keratin -14-expressed human papillomavirus type 16 (K14-HPV-16) transgenic model.
Last Update：2024-04-09 01:59:50
BLZ-945 - Introduction
4-((2-((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide (chemical name: N-(3-(3, 5-dichlorophenyl)-4-methoxyphenyl)-2-ethylaniline) is a compound, which belongs to potential anti-tumor drugs.
4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide, it is a solid with a white or yellowish white crystalline powder in appearance. It is soluble in some organic solvents at room temperature and has good thermal stability.
4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide usage, it is mainly used in the field of research, especially in the field of cancer treatment. According to research, 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide are able to inhibit the growth and spread of certain types of tumor cells, thus providing a possible direction for anti-tumor therapy.
4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-The preparation of N-MethylpicolinaMide is mainly carried out by a series of organic synthetic chemical reactions. The details of the specific preparation may involve some professional experimental techniques, so the safety and operation skills in the laboratory environment are important. To prepare this compound, consult a chemical professional or relevant research institution.
Security information about 4-((2-((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide, it is very important to understand and deal with the security problem correctly. As this compound is a potential drug candidate, its toxic or ecotoxic properties have not been extensively studied at present. When conducting research or experimental operations, follow the appropriate safety practices and guidelines, wear personal protective equipment, and ensure that the operation is carried out in a suitable environment, to minimize any potential risks. Before using or handling 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide, it is recommended to consult a professional, for the latest safety information and operational guidance.
4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide, it is a solid with a white or yellowish white crystalline powder in appearance. It is soluble in some organic solvents at room temperature and has good thermal stability.
4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide usage, it is mainly used in the field of research, especially in the field of cancer treatment. According to research, 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide are able to inhibit the growth and spread of certain types of tumor cells, thus providing a possible direction for anti-tumor therapy.
4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-The preparation of N-MethylpicolinaMide is mainly carried out by a series of organic synthetic chemical reactions. The details of the specific preparation may involve some professional experimental techniques, so the safety and operation skills in the laboratory environment are important. To prepare this compound, consult a chemical professional or relevant research institution.
Security information about 4-((2-((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide, it is very important to understand and deal with the security problem correctly. As this compound is a potential drug candidate, its toxic or ecotoxic properties have not been extensively studied at present. When conducting research or experimental operations, follow the appropriate safety practices and guidelines, wear personal protective equipment, and ensure that the operation is carried out in a suitable environment, to minimize any potential risks. Before using or handling 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide, it is recommended to consult a professional, for the latest safety information and operational guidance.
Last Update：2024-04-09 21:54:55
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Product Name: BLZ945 Visit Supplier Webpage Request for quotationCAS: 953769-46-5
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Spot supply
Product Name: BLZ945 Visit Supplier Webpage Request for quotationCAS: 953769-46-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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