BML-284(HYDROCHLORIDE)

Name	BML-284 HCL
Synonyms	BML-284 HCL AMBMP hydrochloride BML-284(HYDROCHLORIDE) BML-284 (hydrochloride) N4-(Benzo[d][1,3]dioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine hydrochloride
CAS	2095432-75-8

Molecular Formula	C19H19ClN4O3
Molar Mass	386.83216
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
In vitro study	Wnt agonist 1 does not inhibit GSK-3β activity and may serve as a useful tool for the study of physiological processes involved in the Wnt pathway. Exposure of hCMEC/D3 cells to Wnt agonist 1 caused an increase in the proportion of cells with nuclear or perinuclear β-catenin expression (10 or 20 μm, 16 h).
In vivo study	In the African toad model, Wnt agonist 1 (10 μm) mimics the role of Wnt in the whole organism and affects toad embryonic head differentiation. In a rat renal ischemia-reperfusion model, Wnt agonist 1 significantly reduced the plasma concentrations of creatinine, AST and LDH, and inhibited IL-6, IL-1β production and MPO activity. Wnt agonist 1 was also able to reduce renal iNOS, nitrotyrosine proteins and hydroxynonenal (4-hydroxynononenal) after renal ischemia-reperfusion, wnt agonist 1 improves kidney regeneration and its function, reducing inflammation and oxidative stress.

biological activity	Wnt agnist 1 (BML-284 HCL, AMBMP HCL) is a cell-permeable activator of the Wnt signaling pathway, induction is dependent on the transcriptional activity of β-catenin-and TCF-with an EC50 of 0.7 μm.
Target	Value

Last Update：2024-04-09 21:04:16

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Product Name: BML-284 HCL Visit Supplier Webpage Request for quotation
CAS: 2095432-75-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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BML-284(HYDROCHLORIDE)
529-28-2

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