Molecular Formula | C24H24ClFN2O |
Molar Mass | 410.91 |
Density | 1?+-.0.06 g/cm3(Predicted) |
Boling Point | 606.8±45.0 °C(Predicted) |
Solubility | DMSO : 50 mg/mL (121.68 mM; Need ultrasonic);H2O : < 0.1 mg/mL (insoluble) |
pKa | 13.80±0.70(Predicted) |
Storage Condition | -20℃ |
In vitro study | In IDO1-HEK293 cells, BMS-986205 effectively inhibited the production of kynurine with an IC50 of 1.1 nM. There was no such effect in TDO-HEK293 cells. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.434 ml | 12.168 ml | 24.336 ml |
5 mM | 0.487 ml | 2.434 ml | 4.867 ml |
10 mM | 0.243 ml | 1.217 ml | 2.434 ml |
5 mM | 0.049 ml | 0.243 ml | 0.487 ml |